Evidence map›Paper›PMID 30065315›Full record

ArticleCell research2018

Suppression of m

Zhenrui Li, Pengxu Qian, Wanqing Shao, Hailing Shi, Xi C He, Madelaine Gogol, Zulin Yu, Yongfu Wang, Meijie Qi, Yunfei Zhu and 21 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 186 papers.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 256 citations in OpenAlex.

  1. Review
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  10. NNature reviews. Cancer · 2026
    Review
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  13. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. mCells · 2025
    Review
  18. Article
  19. Biomolecular condensates in immune cell fate.Nature reviews. Immunology · 2025
    Review
  20. mAutism research : official journal of the International Society for Autism Research · 2025
    Article

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 4 institutions in 2 countries.

Zhenrui LiStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Pengxu QianStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Wanqing ShaoStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Hailing ShiDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, 60637, USA.
Xi C HeStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Madelaine GogolStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Zulin YuStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Yongfu WangStowers Institute for Medical Research, Kansas City, MO, 64110, USA.ORCID http://orcid.org/0000-0003-3499-0586
Meijie QiState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.
Yunfei ZhuState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.
John M PerryStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Kai ZhangStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Fang TaoStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Kun ZhouStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Deqing HuStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Yingli HanStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Chongbei ZhaoStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Richard AlexanderStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Hanzhang XuShanghai JiaoTong University School of Medicine, Shanghai, 200025, China.
Shiyuan ChenStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Allison PeakStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Kathyrn HallStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Michael PetersonStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Anoja PereraStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Jeffrey S HaugStowers Institute for Medical Research, Kansas City, MO, 64110, USA.ORCID http://orcid.org/0000-0001-8125-3269
Tari ParmelyStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Hua LiStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Bin ShenState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0000-0002-8946-8448
Julia ZeitlingerStowers Institute for Medical Research, Kansas City, MO, 64110, USA.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, 60637, USA.ORCID http://orcid.org/0000-0003-4319-7424
Linheng LiStowers Institute for Medical Research, Kansas City, MO, 64110, USA. Lil@stowers.org.ORCID http://orcid.org/0000-0001-9963-430X
Stowers Institute for Medical Research · USNanjing Medical University · CNHoward Hughes Medical Institute · USShanghai Jiao Tong University · CN

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA168524
6 · The paper itself

Abstract

Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB) holds great promise for treating a broad spectrum of hematological disorders including cancer. However, the limited number of HSCs in a single hUCB unit restricts its widespread use. Although extensive efforts have led to multiple methods for ex vivo expansion of human HSCs by targeting single molecules or pathways, it remains unknown whether it is possible to simultaneously manipulate the large number of targets essential for stem cell self-renewal. Recent studies indicate that N

Indexed as

Cell Self RenewalAdenosineAnimalsHematopoietic Stem CellsMiceMice, KnockoutRNA-Binding ProteinsAdenosineN-methyladenosineRNA-Binding ProteinsYTHDF2 protein, mouse

Identifiers

PMID30065315
PMCPMC6123498
OpenAlexW2885965305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.