ArticleThe ISME journal2018
Low spatial structure and selection against secreted virulence factors attenuates pathogenicity in Pseudomonas aeruginosa.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
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- Can commensals alter pathogen's antibiotic resistance during co-culture?Journal of medical microbiology · 2026Article
- Experimental evolution of yeast shows that public-goods upregulation can evolve despite challenges from exploitative non-producers.Nature communications · 2024Article
- RNA-Seq reveals that Pseudomonas aeruginosa mounts growth medium-dependent competitive responses when sensing diffusible cues from Burkholderia cenocepacia.Communications biology · 2024Article
- Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments.The ISME journal · 2024Article
- Predicting bacterial interaction outcomes from monoculture growth and supernatant assays.ISME communications · 2024Article
- The combinatorial applications of 1,4-naphthoquinone and tryptophan inhibit the biofilm formation of Staphylococcus aureus.Folia microbiologica · 2023Article
- Negative interactions and virulence differences drive the dynamics in multispecies bacterial infections.Proceedings. Biological sciences · 2023Article
- The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogenEvolutionary applications · 2023Article
- Piperine Exhibits Potential Antibiofilm Activity Against Pseudomonas aeruginosa by Accumulating Reactive Oxygen Species, Affecting Cell Surface Hydrophobicity and Quorum Sensing.Applied biochemistry and biotechnology · 2023Article
- Selecting for infectivity across metapopulations can increase virulence in the social microbeEvolutionary applications · 2023Article
- Disturbing the Spatial Organization of Biofilm Communities Affects Expression ofApplied and environmental microbiology · 2023Article
- Copper selects for siderophore-mediated virulence in Pseudomonas aeruginosa.BMC microbiology · 2022Article
- Evolution of Quorum Sensing inmSystems · 2022Article
- Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence.Applied and environmental microbiology · 2022Article
- Evolution of the Quorum Sensing Regulon in Cooperating Populations of Pseudomonas aeruginosa.mBio · 2022Article
- Genomic and Metabolic Characteristics of the Pathogenicity inInternational journal of molecular sciences · 2021Review
- Periodically Disturbing the Spatial Structure of Biofilms Can Affect the Production of an Essential Virulence Factor inmSystems · 2021Article
- Ecology drives the evolution of diverse social strategies in Pseudomonas aeruginosa.Molecular ecology · 2021Article
- Loss of a pyoverdine secondary receptor in Pseudomonas aeruginosa results in a fitter strain suitable for population invasion.The ISME journal · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 5 countries.
Funding
Abstract
Bacterial opportunistic pathogens are feared for their difficult-to-treat nosocomial infections and for causing morbidity in immunocompromised patients. Here, we study how such a versatile opportunist, Pseudomonas aeruginosa, adapts to conditions inside and outside its model host Caenorhabditis elegans, and use phenotypic and genotypic screens to identify the mechanistic basis of virulence evolution. We found that virulence significantly dropped in unstructured environments both in the presence and absence of the host, but remained unchanged in spatially structured environments. Reduction of virulence was either driven by a substantial decline in the production of siderophores (in treatments without hosts) or toxins and proteases (in treatments with hosts). Whole-genome sequencing of evolved clones revealed positive selection and parallel evolution across replicates, and showed an accumulation of mutations in regulator genes controlling virulence factor expression. Our study identifies the spatial structure of the non-host environment as a key driver of virulence evolution in an opportunistic pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.