ArticleThe ISME journal2018
Acquisition of MACPF domain-encoding genes is the main contributor to LPS glycan diversity in gut Bacteroides species.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- High-throughput analyses ofGut microbes · 2026Article
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- A commensal bacterium secretes effector proteins to establish population heterogeneity in the gut.Cell host & microbe · 2025Article
- Interbacterial warfare in the human gut: insights from Bacteroidales' perspective.Gut microbes · 2025Review
- Lessons from the model gut BacteroidalesJournal of bacteriology · 2025Review
- A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues.Nature communications · 2024Article
- Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species- and strain-level diversity and evolution.Cell host & microbe · 2024Article
- Mechanisms of bacterial immunity, protection, and survival during interbacterial warfare.Cell host & microbe · 2024Review
- Bacteria on the foundational kelp in kelp forest ecosystems: Insights from culturing, whole genome sequencing and metabolic assays.Environmental microbiology reports · 2024Article
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- Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome.Nature microbiology · 2024Article
- Bioinformatic mining for RiPP biosynthetic gene clusters in Bacteroidales reveals possible new subfamily architectures and novel natural products.Frontiers in microbiology · 2023Article
- The establishment of the gut microbiota in 1-year-aged infants: from birth to family food.European journal of nutrition · 2022Observational
- A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response.Nature communications · 2022Article
- Article
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- A Continuous Battle for Host-Derived Glycans Between a Mucus Specialist and a Glycan GeneralistFrontiers in microbiology · 2021Article
- A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins.mBio · 2020Article
- Streamlined Genetic Manipulation of DiversemBio · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ability to antagonize competing strains and species is often important for bacterial fitness in microbial communities. The extent to which intra-species antagonism drives phenotypic diversity of bacterial species is rarely examined in a comprehensive manner at both the genetic and phenotypic levels. Here we show that for nine abundant human gut Bacteroides species examined, there are only a few LPS glycan genetic types. We show that for a given Bacteroides species, there is a predominant lipopolysaccharide (LPS) glycan locus present in the majority of strains. However, other strains have replacements of glycosyltransferase-encoding genes, in most cases, adjacent to a membrane attack/perforin (MACPF) domain-encoding gene not present in the predominant type. We show that the MACPF genes present in LPS glycan biosynthesis loci of four Bacteroides species encode antimicrobial proteins and in Bacteroides vulgatus and Bacteroides dorei, we show the MACPF toxin targets the LPS of strains with the predominant LPS glycan locus. By a combination of gene deletion and replacement, we converted a MACPF toxin-producing strain into a sensitive strain. Genetic diversity of LPS glycan biosynthesis regions in Bacteroides is similar to phage serotype conversion whereby the receptor is altered to render the strain immune to infection/toxicity, and is a rare example in bacteria of toxin immunity conferred to the toxin-producing strain by replacement of genetic material to modify the receptor rather than by a cognate immunity protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.