ArticleNature communications2018
Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Novel biofilm-targeted therapeutics for oral infections: enzymes, EPS disruptors, phage/CRISPR, photodynamic and cold-plasma approaches - a systematic review.Frontiers in cellular and infection microbiology · 2026Pooled it
- Recent Advances in Caries Prevention and Non-Invasive Management: From Ecological Modulation to Precision Interventions.Dentistry journal · 2026Review
- Exploring the potential of extracellular matrix modulation to modify oral biofilm architecture.Molecular biology reports · 2026Review
- Energy-assisted CRISPR cleavage and probiotic vesicle signaling platform: Microbiome reprogramming for homeostasis.Science advances · 2026Article
- Engineering Catalytic Nanozymes for Antimicrobial Food Systems: Structure-Activity Relationships, Safe-by-Design Principles, and Industrial Translation.Nanomaterials (Basel, Switzerland) · 2026Review
- Interappointment pain reduction with three intracanal medicaments: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Nanomaterial strategies for antibiotic-resistant infections: Mechanistic frameworks, rational design, and clinical translation.Materials today. Bio · 2026Review
- Peroxidase-mimicking chitosan/dextran-coated cobalt ferrite-graphene oxide nanozyme enhances hydrogen peroxide-mediated killing of cariogenic pathogens in dental biofilm models.Scientific reports · 2026Article
- Phage-Inspired Artificial Peroxidases with Robust Sub-Nanometer Cluster Sites for Efficient Oral Biofilm Elimination and Dental Caries Prevention.Nano-micro letters · 2026Article
- Scalable flow synthesis of ultrasmall inorganic nanoparticles for biomedical applications via a confined impinging jet mixer.Scientific reports · 2026Article
- Stimuli-responsive, antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration.International journal of oral science · 2026Review
- Flower-like ferro-polydopamine nanozymes with peroxidase-like activity for early caries prevention.Frontiers in microbiology · 2026Article
- Antimicrobial Nanozymes: Structure-Activity-Guided Design, Synergy, and Applications.Research (Washington, D.C.) · 2026Review
- Development of a fast-crosslinking hydrogel system doped with magnetic mesoporous nanoparticles for sustained fluoride ion release and caries prevention.Frontiers in bioengineering and biotechnology · 2026Article
- Iron-oxide nanoparticles selectively enhance the toxicity of pharmacological ascorbate through hydrogen peroxide-dependent DNA damage in non-small cell lung cancer (NSCLC).Free radical biology & medicine · 2025Article
- Smart biomaterials in restorative dentistry: Recent advances and future perspectives.Materials today. Bio · 2025Review
- Artificial Intelligence in Endodontics/Robotics- Microrobotics in Endodontics: A Revolutionary Approach to Root Canal Treatment and Nanozymes.Dental clinics of North America · 2025Review
- Nanozymes for Treating Ocular Diseases.Advanced healthcare materials · 2025Review
- Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- Active Microrobots for Dual Removal of Biofilms via Chemical and Physical Mechanisms.ACS applied materials & interfaces · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
Ferumoxytol is a nanoparticle formulation approved by the U.S. Food and Drug Administration for systemic use to treat iron deficiency. Here, we show that, in addition, ferumoxytol disrupts intractable oral biofilms and prevents tooth decay (dental caries) via intrinsic peroxidase-like activity. Ferumoxytol binds within the biofilm ultrastructure and generates free radicals from hydrogen peroxide (H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.