Evidence map›Paper›PMID 30065198›Full record

ArticleInternational journal of molecular sciences2018

Immune Cell Induced Migration of Osteoprogenitor Cells Is Mediated by TGF-β Dependent Upregulation of NOX4 and Activation of Focal Adhesion Kinase.

Sabrina Ehnert, Caren Linnemann, Romina H Aspera-Werz, Daria Bykova, Sara Biermann, Leonie Fecht, Peter M De Zwart, Andreas K Nussler, Fabian Stuby

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sabrina EhnertSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. sabrina.ehnert@med.uni-tuebingen.de.ORCID 0000-0003-4347-1702
Caren LinnemannSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. caren.linnemann@student.uni-tuebingen.de.
Romina H Aspera-WerzSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. rominaaspera@hotmail.com.
Daria BykovaSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. daria.bykova@student.uni-tuebingen.de.
Sara BiermannSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. sarabiermann@web.de.
Leonie FechtSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. leonie.fecht@web.de.
Peter M De ZwartDepartment of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. pdezwart@bgu-tuebingen.de.
Andreas K NusslerSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. andreas.nuessler@gmail.com.ORCID 0000-0002-6666-6791
Fabian StubyDepartment of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, 72076 Tuebingen, Germany. fstuby@bgu-tuebingen.de.ORCID 0000-0002-9952-970X
University of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cytokines secreted by immune cells have a large impact on the tissue, surrounding a fracture, e.g., by attraction of osteoprogenitor cells. However, the underlying mechanisms are not yet fully understood. Thus, this study aims at investigating molecular mechanisms of the immune cell-mediated migration of immature primary human osteoblasts (phOBs), with transforming growth factor beta (TGF-β), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (

Indexed as

Cell DifferentiationCell MovementCells, CulturedFocal Adhesion Protein-Tyrosine KinasesHL-60 CellsHumansNADPH Oxidase 4PhosphorylationReactive Oxygen SpeciesSignal TransductionTetradecanoylphorbol AcetateTHP-1 CellsTransforming Growth Factor betaFocal Adhesion Protein-Tyrosine KinasesNADPH Oxidase 4phorbolol myristate acetateReactive Oxygen SpeciesTetradecanoylphorbol AcetateTransforming Growth Factor betafocal adhesion kinase (FAK)migrationNADPH oxidase 4 (NOX4)primary human osteoblasts (phOBs)

Identifiers

PMID30065198
PMCPMC6121453
OpenAlexW2885413717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.