ArticleProceedings of the National Academy of Sciences of the United States of America2018
Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50citing papers in PubMed
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Who cites it
50 citing papers in PubMed.
- Elucidating the impact of a synonymous SEC24D variant on aberrant splicing in a patient with cole-carpenter syndrome 2.Journal of human genetics · 2026Article
- LSD1 inhibition ameliorates congenital dyserythropoietic anemia type II.Science translational medicine · 2026Article
- Salidroside Selectively Binds to SEC23A and Ameliorates Psychological Stress-Induced Hyperpigmentation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- p27Kip1 regulates γ-globin production.Blood · 2026Article
- Dynamic O-GlcNAcylation of Sec23-interacting protein regulates COPII function.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway.Nature reviews. Molecular cell biology · 2025Review
- A genome-wide screen identifies genes required for erythroid differentiation.Nature communications · 2025Article
- Hereditary disorders of ineffective erythropoiesis.Blood cells, molecules & diseases · 2025Review
- LMAN1 serves as a cargo receptor for thrombopoietin.JCI insight · 2024Article
- Genetics of hemostasis: from bedside to bench and back again.The Journal of clinical investigation · 2024Article
- Functional overlap between the mammalianProceedings of the National Academy of Sciences of the United States of America · 2024Article
- COPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation.Scientific reports · 2024Article
- Functional overlap between the mammalianbioRxiv : the preprint server for biology · 2024Article
- New Cases and Mutations inInternational journal of molecular sciences · 2023Article
- IncreasedCancers · 2023Article
- Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics.Cells · 2023Article
- Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases.The Journal of clinical investigation · 2023Review
- Paralogous Genes Involved in Embryonic Development: Lessons from the Eye and Other Tissues.Genes · 2022Review
- Article
- Identification of Transferrin Receptor 1 (TfR1) Overexpressed in Lung Cancer Cells, and Internalization of Magnetic Au-CoFePharmaceutics · 2022Article
Corrections and comments
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Authors and funding
17 authors.
Rami KhoriatyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; ramikhor@umich.edu ginsburg@umich.edu.
Geoffrey G HeskethLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, M5G 1X5 ON, Canada.
Amélie BernardLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Angela C WeyandDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109.
Dattatreya MellacheruvuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109.
Guojing ZhuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Mark J HoenerhoffIn Vivo Animal Core, Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109.
Beth McGeeLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Lesley EverettLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Elizabeth J AdamsLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Bin ZhangGenomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44106.
Thomas L SaundersTransgenic Animal Model Core, University of Michigan, Ann Arbor, MI 48109.
Alexey I NesvizhskiiDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109.
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Jordan A ShavitProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, M5G 1X5 ON, Canada.
David GinsburgDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; ramikhor@umich.edu ginsburg@umich.edu.ORCID 0000-0002-6436-8942
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2MTRANSGENIC MODELS FOR THE STUDY OF FACTOR V FUNCTIONP01HL057346 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GORDON, DAVID · 1997 to 2013
$19.9MCELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8MALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEASTR01GM053396 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLIONSKY, DANIEL J. · 1995 to 2018
$12.1MTraining Program in Molecular HematologyT32HL007622 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI, Jordan A. Shavit · 1986 to 2026
$9.2MCOMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATAR01GM094231 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 2010 to 2026
$5.4MER-to-Golgi transport of coagulation factors V and VIIIR01HL094505 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZHANG, BIN · 2009 to 2022
$5.1MThe Molecular Genetics of HemostasisR35HL135793 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 2017 to 2023
$4.1MMolecular Genetic Study of von Willebrand FactorR01HL039693 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 1989 to 2016
$2.4MDissecting the Genetics of Human Hemostatic Disorders Using ZebrafishR01HL124232 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAVIT, JORDAN A · 2015 to 2019
$1.9MThe Evolution of the Mammalian SEC23 Paralogs and the Molecular Pathogenesis of Congenital Dyserythropoietic Anemia type IIK08HL128794 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHORIATY, RAMI · 2015 to 2019
$812kCIHR FDN 143301Howard Hughes Medical InstituteNCI NIH HHS P30 CA046592NHLBI NIH HHS K08 HL128794NHLBI NIH HHS P01 HL057346NHLBI NIH HHS R01 HL039693NHLBI NIH HHS R01 HL094505NHLBI NIH HHS R01 HL124232NHLBI NIH HHS R35 HL135793NHLBI NIH HHS T32 HL007622NIGMS NIH HHS R01 GM053396NIGMS NIH HHS R01 GM094231NIGMS NIH HHS T32 GM007315
Abstract
Approximately one-third of the mammalian proteome is transported from the endoplasmic reticulum-to-Golgi via COPII-coated vesicles. SEC23, a core component of coat protein-complex II (COPII), is encoded by two paralogous genes in vertebrates (
Indexed as
Anemia, Dyserythropoietic, CongenitalBone MarrowCOP-Coated VesiclesErythrocytesGene Expression RegulationHEK293 CellsHumansMultiprotein ComplexesSpecies SpecificityVesicular Transport ProteinsMultiprotein ComplexesSEC23A protein, humanSec23a protein, mouseSEC23B protein, humanSEC23B protein, mouseVesicular Transport Proteinsendoplasmic reticulummiceSEC23transgenicvesicular transport proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.