Evidence map›Paper›PMID 30065095›Full record

ArticlemBio2018

Reverse Genetics for Type I Feline Coronavirus Field Isolate To Study the Molecular Pathogenesis of Feline Infectious Peritonitis.

Rosina Ehmann, Claudia Kristen-Burmann, Barbara Bank-Wolf, Matthias König, Christiane Herden, Torsten Hain, Heinz-Jürgen Thiel, John Ziebuhr, Gergely Tekes

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rosina EhmannInstitute of Virology, Justus Liebig University Giessen, Giessen, Germany.
Claudia Kristen-BurmannInstitute of Virology, Justus Liebig University Giessen, Giessen, Germany.
Barbara Bank-WolfInstitute of Virology, Justus Liebig University Giessen, Giessen, Germany.
Matthias KönigInstitute of Virology, Justus Liebig University Giessen, Giessen, Germany.
Christiane HerdenInstitute of Veterinary Pathology, Justus Liebig University Giessen, Giessen, Germany.
Torsten HainInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, Germany.
Heinz-Jürgen ThielInstitute of Virology, Justus Liebig University Giessen, Giessen, Germany.
John ZiebuhrInstitute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.
Gergely TekesInstitute of Virology, Justus Liebig University Giessen, Giessen, Germany gergely.tekes@vetmed.uni-giessen.de.
University of Giessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline infectious peritonitis (FIP), one of the most important lethal infections of cats, is caused by feline infectious peritonitis virus (FIPV), the high-virulence biotype of feline coronaviruses (FCoVs). FIPVs are suggested to emerge from feline enteric coronaviruses (FECVs) by acquiring mutations in specific genes in the course of persistent infections. Although numerous studies identified mutations predicted to be responsible for the FECV-FIPV biotype switch, the presumed roles of specific genetic changes in FIP pathogenesis have not been confirmed experimentally. Reverse genetics systems established previously for serotype I and the less common serotype II FCoVs were based on cell culture-adapted FIPV strains which, however, were shown to be unsuitable for FIP pathogenesis studies

Indexed as

AnimalsCatsCoronavirus, FelineFeline Infectious PeritonitisReverse GeneticsVirologyfeline coronavirus field isolatesfeline infectious peritonitisreverse genetics

Identifiers

PMID30065095
PMCPMC6069117
OpenAlexW2887442143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.