Evidence map›Paper›PMID 30065091›Full record

ArticlemBio2018

A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis.

Kristy Koselny, Nebibe Mutlu, Annabel Y Minard, Anuj Kumar, Damian J Krysan, Melanie Wellington

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Lack of an atypical PDR transporter generates an immunogenicbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Use of the D4H Probe to Track Sterols in Yeast.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Pyroptosis in microbial infectious diseases.Molecular biology reports · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Extension ofmBio · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kristy KoselnyDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.
Nebibe MutluDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Annabel Y MinardDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Anuj KumarDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Damian J KrysanDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA damian-krysan@uiowa.edu melanie-wellington@uiowa.edu.
Melanie WellingtonDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA damian-krysan@uiowa.edu melanie-wellington@uiowa.edu.
University of Iowa · USUniversity of Michigan–Ann Arbor · USUniversity of Rochester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen

Indexed as

Host-Pathogen InteractionsPyroptosisAnimalsCandida albicansCandidiasisCell LineCryptococcus neoformansDisease Models, AnimalErgosterolGene DeletionGenetic TestingHistocytochemistryKidneyMacrophagesMiceSaccharomyces cerevisiaeErgosterolCandida albicansinflammasomepyroptosis

Identifiers

PMID30065091
PMCPMC6069111
OpenAlexW2885807142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.