Evidence map›Paper›PMID 30065086›Full record

ArticlemBio2018

An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.

Nabanita Bhattacharyya, Irene Nailain Nkumama, Zaccheus Newland-Smith, Li-Ying Lin, Wen Yin, Rebecca E Cullen, Jack S Griffiths, Alexander R Jarvis, Michael J Price, Pei Ying Chong and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. MedComm · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Virulence-Associated Secretion inFrontiers in immunology · 2022
    Review
  14. Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Article
  16. Review
  17. Deletion ofAntimicrobial agents and chemotherapy · 2021
    Article
  18. The role of solute binding proteins in signal transduction.Computational and structural biotechnology journal · 2021
    Review
  19. Senescence in Bacteria and Its Underlying Mechanisms.Frontiers in cell and developmental biology · 2021
    Review
  20. Physicochemical properties andRSC medicinal chemistry · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Nabanita Bhattacharyya *Leicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Irene Nailain Nkumama *Leicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Zaccheus Newland-Smith *Leicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Li-Ying LinLeicester Drug Discovery and Diagnostics, University of Leicester, Leicester, United Kingdom.
Wen YinLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Rebecca E CullenLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Jack S GriffithsLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Alexander R JarvisLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Michael J PriceLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Pei Ying ChongLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Russell WallisLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Helen M O'HareLeicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom hmo7@le.ac.uk.ORCID 0000-0002-8666-7433
University of Leicester · GB

Funding

Medical Research Council MC_PC_15045Medical Research Council MC_PC_15056Medical Research Council MC_PC_16051
6 · The paper itself

Abstract

Signaling by serine/threonine phosphorylation controls diverse processes in bacteria, and identification of the stimuli that activate protein kinases is an outstanding question in the field. Recently, we showed that nutrients stimulate phosphorylation of the protein kinase G substrate GarA in

Indexed as

Signal TransductionCyclic GMP-Dependent Protein KinasesGene Expression Regulation, BacterialGlutamic AcidHumansMycobacteriumSolute Carrier ProteinsCyclic GMP-Dependent Protein KinasesGlutamic AcidSolute Carrier ProteinsActinobacteriaCorynebacteriumMycobacterium tuberculosissensory transduction processesserine/threonine kinasesstructural biology

Identifiers

PMID30065086
PMCPMC6069109
OpenAlexW2885906230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.