Evidence map›Paper›PMID 30064895›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2018

Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy.

Koji M Nishiguchi, Kosuke Fujita, Naoyuki Tokashiki, Hiroshi Komamura, Sayaka Takemoto-Kimura, Hiroyuki Okuno, Haruhiko Bito, Toru Nakazawa

Open access · hybridAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. MEF2C and HDAC5 regulateNeuronal signaling · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Koji M NishiguchiDepartment of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan. Electronic address: nishiguchi@oph.med.tohoku.ac.jp.
Kosuke FujitaDepartment of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Naoyuki TokashikiDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Hiroshi KomamuraDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Sayaka Takemoto-KimuraDepartment of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan; PRESTO-Japan Science and Technology Agency, Chiyoda-ku, Tokyo, Japan.
Hiroyuki OkunoMedical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Haruhiko BitoDepartment of Neurochemistry, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Toru NakazawaDepartment of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Tohoku University · JPKyoto University · JPNagoya University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients born blind with retinal dystrophies, understanding the critical periods of cortical plasticity is important for successful visual restoration. In this study, we sought to model childhood blindness and investigate the plasticity of visual pathways. To this end, we generated double-mutant (Pde6c

Indexed as

Genetic TherapyAnimalsBlindnessCyclic Nucleotide Phosphodiesterases, Type 6ElectroretinographyGTP-Binding Protein alpha SubunitsHumansMiceMutationRetinaRetinal Cone Photoreceptor CellsRetinal DystrophiesRetinal Rod Photoreceptor CellsTransducinVisual AcuityVisual CortexCyclic Nucleotide Phosphodiesterases, Type 6Gnat1 protein, mouseGTP-Binding Protein alpha SubunitsTransducincortical plasticitygene therapyphotoreceptorsretinal degeneration

Identifiers

PMID30064895
PMCPMC6171050
OpenAlexW2883882942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.