Evidence map›Paper›PMID 30064468›Full record

ArticleParasites & vectors2018

Hints on T cell responses in a fish-parasite model: Enteromyxum leei induces differential expression of T cell signature molecules depending on the organ and the infection status.

M Carla Piazzon, Itziar Estensoro, Josep A Calduch-Giner, Raquel Del Pozo, Amparo Picard-Sánchez, Jaume Pérez-Sánchez, Ariadna Sitjà-Bobadilla

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  4. Article
  5. Infection by the ParasiteMicroorganisms · 2022
    Article
  6. Severe Natural Outbreak ofInternational journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

M Carla PiazzonFish Pathology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Itziar EstensoroFish Pathology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Josep A Calduch-GinerNutrigenomics and Fish Growth Endocrinology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Raquel Del PozoFish Pathology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Amparo Picard-SánchezFish Pathology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Jaume Pérez-SánchezNutrigenomics and Fish Growth Endocrinology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Ariadna Sitjà-BobadillaFish Pathology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Ribera de Cabanes, Castellón, Spain. ariadna.sitja@csic.es.ORCID http://orcid.org/0000-0002-7473-3413
Instituto de Acuicultura Torre de la Sal · ES

Funding

Consejo Superior de Investigaciones Científicas PIE project no. 201740E013Generalitat Valenciana APOSTD/2016/037Generalitat Valenciana PROMETEOII/2014/085H2020 Food 634429Secretaría de Estado de Investigación, Desarrollo e Innovación AGL2013-48560-R-C2-1Secretaría de Estado de Investigación, Desarrollo e Innovación AGL2013-48560-R-C2-2
6 · The paper itself

Abstract

backgroudEnteromyxum leei is a myxozoan parasite that produces a slow-progressing intestinal disease. This parasite invades the paracellular space of the intestinal epithelium and progresses from the posterior to the anterior intestine. The aim of the present study was to gain insights into fish T cell responses in the gilthead sea bream-E. leei infection model using a PCR-array with 30 signature molecules for different leukocyte responses in head kidney, spleen, anterior and posterior intestine.

resultsThe PCR-array results suggest that E. leei induced migration of T cells from head kidney to intestines where T

conclusionsThese results evidence a clear modulation of the T cell response of gilthead sea bream upon E. leei infection. The effects occurred both at local and systemic levels, but the response was stronger and more specific at the site of infection, the intestine. Altogether, this research poses a promising basis to understand the response against this important parasite and establish effective preventive or palliative measures.

Indexed as

AnimalsBiomarkersFish DiseasesGene Expression RegulationMyxozoaParasitic Diseases, AnimalT-LymphocytesBiomarkersCytokinesGilthead sea breamMyxozoaTeleostT lymphocytes

Identifiers

PMID30064468
PMCPMC6069777
OpenAlexW2887453900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.