Evidence map›Paper›PMID 30063811›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

Temporal changes in the composition of a large multicenter kidney exchange clearinghouse: Do the hard-to-match accumulate?

Courtenay M Holscher, Kyle Jackson, Alvin G Thomas, Christine E Haugen, Sandra R DiBrito, Karina Covarrubias, Sommer E Gentry, Matthew Ronin, Amy D Waterman, Allan B Massie and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The benefit to waitlist patients in a national paired kidney exchange program: Exploring characteristics of chain end living donor transplants.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  5. Early graft losses in paired kidney exchange: Experience from 10 years of the National Kidney Registry.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  6. Article
  7. Patient and Kidney Allograft Survival with National Kidney Paired Donation.Clinical journal of the American Society of Nephrology : CJASN · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Courtenay M HolscherDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5808-5954
Kyle JacksonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alvin G ThomasDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4911-8192
Christine E HaugenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5884-2604
Sandra R DiBritoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karina CovarrubiasDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sommer E GentryDepartment of Mathematics, United States Naval Academy, Annapolis, MD, USA.ORCID 0000-0003-4530-8917
Matthew RoninNational Kidney Registry, New York, NY, USA.
Amy D WatermanDavid Geffen School of Medicine at UCLA, Kidney Transplant Program, Los Angeles, CA, USA.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacqueline Garonzik WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Quantifying Risk And Survival Benefit from Incompatible Kidney TransplantationR01DK098431 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.7M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Differential Survival Benefit of Incompatible Living Donor Kidney Transplantation: Modeling Outcomes for Different Patient PhenotypesF32DK113719 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JACKSON, KYLE R · 2017 to 2019
$238k
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
Health Care Utilization and Race: Live Kidney Donor Risks and OutcomesF32DK105600 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DIBRITO, SANDRA RENAE · 2015 to 2017
$227k
Novel Frailty Phenotype in Older Adults with End-Stage Renal DiseaseF32AG053025 · NIA · JOHNS HOPKINS UNIVERSITY · PI HAUGEN, CHRISTINE · 2016 to 2019
$204k
NIA NIH HHS F32 AG053025NIA NIH HHS F32AG053025NIDDK NIH HHS F32 DK105600NIDDK NIH HHS F32DK105600NIDDK NIH HHS F32 DK109662NIDDK NIH HHS F32DK109662NIDDK NIH HHS F32 DK113719NIDDK NIH HHS F32DK113719NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K01DK101677NIDDK NIH HHS K24 DK101828NIDDK NIH HHS K24DK101828NIDDK NIH HHS R01 DK098431NIDDK NIH HHS R01DK098431
6 · The paper itself

Abstract

One criticism of kidney paired donation (KPD) is that easy-to-match candidates leave the registry quickly, thus concentrating the pool with hard-to-match sensitized and blood type O candidates. We studied candidate/donor pairs who registered with the National Kidney Registry (NKR), the largest US KPD clearinghouse, from January 2012-June 2016. There were no changes in age, gender, BMI, race, ABO blood type, or panel-reactive antibody (PRA) of newly registering candidates over time, with consistent registration of hard-to-match candidates (59% type O and 38% PRA ≥97%). However, there was no accumulation of type O candidates over time, presumably due to increasing numbers of nondirected type O donors. Although there was an initial accumulation of candidates with PRA ≥97% (from 33% of the pool in 2012% to 43% in 2014, P = .03), the proportion decreased to 17% by June 2016 (P < .001). Some of this is explained by an increase in the proportion of candidates with PRA ≥97% who underwent a deceased donor kidney transplantation (DDKT) after the implementation of the Kidney Allocation System (KAS), from 8% of 2012 registrants to 17% of 2015 registrants (P = .02). In this large KPD clearinghouse, increasing participation of nondirected donors and the KAS have lessened the accumulation of hard-to-match candidates, but highly sensitized candidates remain hard-to-match.

Indexed as

Kidney TransplantationBlood Grouping and CrossmatchingDonor SelectionFemaleFollow-Up StudiesHistocompatibility TestingHumansMaleMiddle AgedMulticenter Studies as TopicPrognosisRegistriesTissue and Organ ProcurementTissue Donorsdonors and donation: livingdonors and donation: paired exchangehealth services and outcomes researchkidney transplantation: living donorkidney transplantation/nephrologysensitization

Identifiers

PMID30063811
PMCPMC6287934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.