Evidence map›Paper›PMID 30063654›Full record

Observational studyPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2018

Epidemiology of Disease and Mortality From a PICU in Mozambique.

Maria Punchak, Kaitlin Hall, Amir Seni, W Chris Buck, Daniel A DeUgarte, Emily Hartford, Robert B Kelly, Valéria I Muando

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. Paediatric emergency care at an academic referral hospital in Mozambique.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Maria PunchakDavid Geffen School of Medicine at UCLA, Los Angeles, CA.
Kaitlin HallDavid Geffen School of Medicine at UCLA, Los Angeles, CA.
Amir SeniHospital Central de Maputo, Maputo, Mozambique.
W Chris BuckDavid Geffen School of Medicine at UCLA, Los Angeles, CA.
Daniel A DeUgarteDavid Geffen School of Medicine at UCLA, Los Angeles, CA.
Emily HartfordDavid Geffen School of Medicine at UCLA, Los Angeles, CA.
Robert B KellyDavid Geffen School of Medicine at UCLA, Los Angeles, CA.
Valéria I MuandoHospital Central de Maputo, Maputo, Mozambique.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124PEPFAR
6 · The paper itself

Abstract

objectivesDelivery of pediatric critical care in low-income countries is limited by a lack of infrastructure, resources, and providers. Few studies have analyzed the epidemiology of disease associated with a PICU in a low-income country. The aim of this study was to document the primary diagnoses and the associated mortality rates of patients presenting to a tertiary PICU in Mozambique in order to formulate quality improvement projects through an international academic partnership. We hypothesized that the PICU mortality rate would be high and that sepsis would be a common cause of death.

designRetrospective, observational study.

settingTertiary academic PICU. PATIENTS: All admitted PICU patients.

interventionsAll available data collection forms containing demographic and clinical data of patients admitted to the PICU at Hospital Central de Maputo, Mozambique from January 2013 to December 2013 were analyzed retrospectively. MEASUREMENTS AND MAIN

resultsThe patient median age was 2 years (57% male). The most common primary diagnoses were malaria (22%), sepsis (18%), respiratory tract infections (12%), and trauma (6%). The mortality rate was 25%. Mortality rates were highest among patients with sepsis (59%), encephalopathy (56%), noninfectious CNS pathologies (33%), neoplastic diseases (33%), meningitis/encephalitis (29%), burns (26%), and cardiovascular pathologies (26%). The median length of PICU stay was 2 days. HIV exposure/infection had a nonstatistically significant association with mortality. Patients admitted for burns had the highest median length of PICU stay (4 d). Most trauma admissions were male (75%), and approximately half of all trauma admissions had an associated head injury (55%).

conclusionsInfectious disease and trauma were highly represented in this Mozambican PICU, and overall mortality was high compared with high-income countries. With this knowledge, targeted collaborative projects in Mozambique can now be created and modified. Further research is needed to monitor the potential benefits of such interventions.

Indexed as

Child MortalityHospital MortalityAdolescentCause of DeathChildChild, PreschoolCritical CareFemaleHIV InfectionsHumansInfantInfant, NewbornIntensive Care Units, PediatricLength of StayMalariaMale

Identifiers

PMID30063654
PMCPMC6218274

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.