Evidence map›Paper›PMID 30063383›Full record

Trial reportThe British journal of radiology2018

MRI guided stereotactic radiotherapy for locally advanced pancreatic cancer.

Hanne D Heerkens, Marco van Vulpen, Beth Erickson, Onne Reerink, Martijn Pw Intven, Cornelis At van den Berg, I Quintus Molenaar, Frank P Vleggaar, Gert J Meijer

Registry-linked trialAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01898741 (Cone-beam CT Guided Stereotactic Radiation Therapy for Locally Advanced Pancreatic Cancer), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01898741 phase2unknown statusnot on this map

Cone-beam CT Guided Stereotactic Radiation Therapy for Locally Advanced Pancreatic Cancer

TypeinterventionalSponsorUMC UtrechtRan2013 to 2016Enrolled30ConditionsPancreatic CancerArms24 Gy in 3 fractions
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanne D Heerkens1 Department of Radiation Oncology, University Medical Center Utrecht , Utrecht , The Netherlands.
Marco van Vulpen1 Department of Radiation Oncology, University Medical Center Utrecht , Utrecht , The Netherlands.
Beth Erickson3 Department of Radiation Oncology, Medical College of Wisconsin , Milwaukee, WI , USA.
Onne Reerink4 Department of Radiation Oncology, Isala Clinic , Zwolle , The Netherlands.
Martijn Pw Intven1 Department of Radiation Oncology, University Medical Center Utrecht , Utrecht , The Netherlands.
Cornelis At van den Berg1 Department of Radiation Oncology, University Medical Center Utrecht , Utrecht , The Netherlands.
I Quintus Molenaar5 Department of Surgery, University Medical Center Utrecht , Utrecht , The Netherlands.
Frank P Vleggaar6 Department of Gastroenterology, University Medical Center Utrecht , Utrecht , The Netherlands.
Gert J Meijer1 Department of Radiation Oncology, University Medical Center Utrecht , Utrecht , The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective: We want to explore the safety and technical feasibility of MRI-guided stereotactic radiotherapy for locally advanced pancreatic cancer.

methods: A custom-made abdominal corset was manufactured to reduce breathing induced tumour motion. Delineation of the tumour and organs at risk (OARs) was performed on CT and multiparametric MRI. Tumour motion was quantified with cine MRI. After treatment planning, the static dose distribution was convolved with the cine MRI-based motion trajectory to simulate the delivered dose to the tumour and OARs. Stereotactic body radiation therapy (SBRT) was carried out up to a dose of 24 G in three fractions in 1 week.

results: From July 2013 to January 2016, 20 patients were included. Tumours and OARs were clearly visible with contrast-enhanced CT and MRI. After simulation of the delivered dose taking the motion into account, an adequate target coverage was achieved with acceptable dose in the OARs. No Grade3 or higher treatment related toxicity was observed.

conclusion: MRI-guided SBRT for pancreatic cancer is technical feasible and safe, with no treatment related grade ≥3 toxicity. New strategies are applied, including an individual corset to reduce breathing motion, MRI-based delineation and simulation of motion-integrated dose distributions. ADVANCES IN KNOWLEDGE:: This article is the first to describe an MRI-integrated workflow in SBRT for locally advanced pancreatic cancer. In addition, it demonstrated that SBRT with an abdominal corset to reduce tumour motion is feasible and safe.

trial registration: This trial was registered at www.clinicaltrials.gov (NCT01898741) on July 9, 2013.

Indexed as

AgedAged, 80 and overClothingFeasibility StudiesFemaleFiducial MarkersHumansMagnetic Resonance Imaging, CineMagnetic Resonance Imaging, InterventionalMaleMiddle AgedMovementMultimodal ImagingPancreatic NeoplasmsProspective StudiesQuality of Life

Identifiers

PMID30063383
PMCPMC6475956

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.