Evidence map›Paper›PMID 30063208›Full record

ArticleeLife2018

Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration.

Kieran M Short, Alexander N Combes, Valerie Lisnyak, James G Lefevre, Lynelle K Jones, Melissa H Little, Nicholas A Hamilton, Ian M Smyth

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  6. Review
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  8. Systems for intricate patterning of the vertebrate anatomy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021
    Article
  9. Review
  10. Article
  11. [Acquisition of submandibular gland in mouse embryo and establishment of an in vitro organ culture model].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Statistical theory of branching morphogenesis.Development, growth & differentiation · 2018
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kieran M ShortDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Alexander N CombesMurdoch Children's Research Institute, Parkville, Australia.
Valerie LisnyakDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
James G LefevreDivision of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Lynelle K JonesDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Melissa H LittleMurdoch Children's Research Institute, Parkville, Australia.
Nicholas A HamiltonDivision of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Ian M SmythDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.ORCID https://orcid.org/0000-0002-1727-7829

Funding

Australian Research Council DP160103100Human Frontier Science Program RGP0039/2011National Health and Medical Research Council 1002748National Health and Medical Research Council 1063696
6 · The paper itself

Abstract

Branching morphogenesis of the ureteric bud is integral to kidney development; establishing the collecting ducts of the adult organ and driving organ expansion via peripheral interactions with nephron progenitor cells. A recent study suggested that termination of tip branching within the developing kidney involved stochastic exhaustion in response to nephron formation, with such a termination event representing a unifying developmental process evident in many organs. To examine this possibility, we have profiled the impact of nephron formation and maturation on elaboration of the ureteric bud during mouse kidney development. We find a distinct absence of random branch termination events within the kidney or evidence that nephrogenesis impacts the branching program or cell proliferation in either tip or progenitor cell niches. Instead, organogenesis proceeds in a manner indifferent to the development of these structures. Hence, stochastic cessation of branching is not a unifying developmental feature in all branching organs.

Indexed as

OrganogenesisAnimalsCell ProliferationEmbryo, MammalianGreen Fluorescent ProteinsMiceNephronsUreterGreen Fluorescent Proteinsbranching morphogenesisdevelopmental biologykidney developmentmousenephron formation

Identifiers

PMID30063208
PMCPMC6115188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.