Evidence map›Paper›PMID 30063205›Full record

ArticleeLife2018

Control of the polyamine biosynthesis pathway by G

Helen Louise Lightfoot, Timo Hagen, Antoine Cléry, Frédéric Hai-Trieu Allain, Jonathan Hall

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Sequence and ionic requirements of pUG fold quadruplexes.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. GRNA biology · 2020
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Helen Louise LightfootDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-9292-0087
Timo HagenDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.ORCID 0000-0003-0139-6011
Antoine CléryDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-4550-6908
Frédéric Hai-Trieu AllainDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-2131-6237
Jonathan HallDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.ORCID 0000-0003-4160-7135
ETH Zurich · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung NCCR RNA and Disease
6 · The paper itself

Abstract

G-quadruplexes are naturally-occurring structures found in RNAs and DNAs. Regular RNA G-quadruplexes are highly stable due to stacked planar arrangements connected by short loops. However, reports of irregular quadruplex structures are increasing and recent genome-wide studies suggest that they influence gene expression. We have investigated a grouping of G

Indexed as

G-Quadruplexes5' Untranslated RegionsCarrier ProteinsDNAGene Expression RegulationHumansLigandsMagnetic Resonance SpectroscopyPolyaminesRNA5' Untranslated RegionsAZIN1 protein, humanCarrier ProteinsDNALigandsPolyaminesRNAbiochemistrychemical biologyhumanNMRpolyaminepyridostatinquadruplexRNAthioflavin

Identifiers

PMID30063205
PMCPMC6067879
OpenAlexW2887651904

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.