Evidence map›Paper›PMID 30063195›Full record

ArticleRadiology2018

Deep Learning Approach for Evaluating Knee MR Images: Achieving High Diagnostic Performance for Cartilage Lesion Detection.

Fang Liu, Zhaoye Zhou, Alexey Samsonov, Donna Blankenbaker, Will Larison, Andrew Kanarek, Kevin Lian, Shivkumar Kambhampati, Richard Kijowski

Abstract read
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 2 pooled it
26.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 2 syntheses or guidelines pooled it, 292 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Article
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  8. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
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  12. Effective automatic classification methods via deep learning for multi-type infectious keratitis diagnosis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. AI for Lesion Detection in Musculoskeletal Radiology.Journal of the Korean Society of Radiology · 2025
    Review
  18. Review
  19. Article
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Fang LiuFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).ORCID 0000-0001-8032-6681
Zhaoye ZhouFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
Alexey SamsonovFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
Donna BlankenbakerFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
Will LarisonFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
Andrew KanarekFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
Kevin LianFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
Shivkumar KambhampatiFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
Richard KijowskiFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705-2275 (F.L., A.S., D.B., W.L., A.K., K.L., S.K., R.K.); and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minn (Z.Z.).
University of Wisconsin–Madison · US

Funding

Multi-component T2 and T2* mapping of All Water Components of Articular CartilageR01AR068373 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI KIJOWSKI, RICHARD · 2015 to 2018
$1.4M
NIAMS NIH HHS R01 AR068373
6 · The paper itself

Abstract

Purpose To determine the feasibility of using a deep learning approach to detect cartilage lesions (including cartilage softening, fibrillation, fissuring, focal defects, diffuse thinning due to cartilage degeneration, and acute cartilage injury) within the knee joint on MR images. Materials and Methods A fully automated deep learning-based cartilage lesion detection system was developed by using segmentation and classification convolutional neural networks (CNNs). Fat-suppressed T2-weighted fast spin-echo MRI data sets of the knee of 175 patients with knee pain were retrospectively analyzed by using the deep learning method. The reference standard for training the CNN classification was the interpretation provided by a fellowship-trained musculoskeletal radiologist of the presence or absence of a cartilage lesion within 17 395 small image patches placed on the articular surfaces of the femur and tibia. Receiver operating curve (ROC) analysis and the κ statistic were used to assess diagnostic performance and intraobserver agreement for detecting cartilage lesions for two individual evaluations performed by the cartilage lesion detection system. Results The sensitivity and specificity of the cartilage lesion detection system at the optimal threshold according to the Youden index were 84.1% and 85.2%, respectively, for evaluation 1 and 80.5% and 87.9%, respectively, for evaluation 2. Areas under the ROC curve were 0.917 and 0.914 for evaluations 1 and 2, respectively, indicating high overall diagnostic accuracy for detecting cartilage lesions. There was good intraobserver agreement between the two individual evaluations, with a κ of 0.76. Conclusion This study demonstrated the feasibility of using a fully automated deep learning-based cartilage lesion detection system to evaluate the articular cartilage of the knee joint with high diagnostic performance and good intraobserver agreement for detecting cartilage degeneration and acute cartilage injury. © RSNA, 2018 Online supplemental material is available for this article .

Indexed as

Cartilage, ArticularDeep LearningAdolescentAdultAgedArthralgiaCartilage DiseasesFemaleHumansImage Interpretation, Computer-AssistedKnee InjuriesKnee JointMagnetic Resonance ImagingMaleMiddle AgedRetrospective Studies

Identifiers

PMID30063195
PMCPMC6166867
OpenAlexW2885303411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.