ArticleHuman brain mapping2018
Altered white matter microstructure mediates the relationship between hemoglobin levels and cognitive control deficits in end-stage renal disease patients.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Cingulate Gradient Dysfunction in End-Stage Renal Disease: Associations With Clinical Phenotypes and Exploratory Transcriptomic Signatures.CNS neuroscience & therapeutics · 2026Article
- Brain connectome gradient dysfunction in patients with end-stage renal disease and its association with clinical phenotype and cognitive deficits.Communications biology · 2025Article
- Machine learning-based prediction model for cognitive impairment risk in patients with chronic kidney disease.PloS one · 2025Article
- Nomogram to Estimate the Risk of Chronic Kidney Disease-Associated Pruritus in Patients with End-Stage Renal Disease Undergoing Peritoneal Dialysis: Model Development and Validation Study.Blood purification · 2024Article
- Altered brain texture features in end-stage renal disease patients: a voxel-based 3D brain texture analysis study.Frontiers in neuroscience · 2024Article
- Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease.Renal failure · 2023Article
- Risk factors for neurocognitive impairment and the relation with structural brain abnormality in children and young adults with severe chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Fiber connectivity density mapping in end-stage renal disease patients: a preliminary study.Brain imaging and behavior · 2022Article
- Structural brain abnormalities in children and young adults with severe chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Visual Dysfunction Predicts Cognitive Impairment and White Matter Degeneration in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Dentatorubrothalamic tract reduction using fixel-based analysis in corticobasal syndrome.Neuroradiology · 2021Article
- Vasogenic Brain Edema During Maintenance Hemodialysis : Preliminary Results from Tract-based Spatial Statistics and Voxel-based Morphometry.Clinical neuroradiology · 2021Article
- Fixel Based Analysis Reveals Atypical White Matter Micro- and Macrostructure in Adults With Autism Spectrum Disorder: An Investigation of the Role of Biological Sex.Frontiers in integrative neuroscience · 2020Article
- How Do You Feel Now? The Salience Network Functional Connectivity in End-Stage Renal Disease.Frontiers in neuroscience · 2020Article
- Altered white matter microstructure mediates the relationship between hemoglobin levels and cognitive control deficits in end-stage renal disease patients.Human brain mapping · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain-kidney crosstalk theory suggested that the brain and kidneys may be considered end organs on parallel trajectories and subject to shared risk factors, which are receiving increasing attention. Cognitive control deficits were frequently presented in patients with end-stage renal disease (ESRD). Whether or not cognitive control impairment is concerned with brain-kidney crosstalk is in need of further research. To detect the relationship between ESRD and cognitive control impairment, diffusion tensor imaging was collected in 64 healthy controls (HCs) and 64 patients with ESRD. Tract-based spatial statistics and fixel-based analysis were used to detect the difference of white matter (WM) microstructure and morphology between ESRD patients and HCs in the whole brain. Tractography atlas-based analysis was also used to investigate the difference of diffusional characteristics along fiber bundles of interest between the two groups. For the whole-brain analysis, ESRD patients showed WM microstructural alteration and fiber density variation in the cingulum. In addition, ESRD patients exhibited higher MD and RD than HCs along the anterior cingulum. Among all of the blood biochemistry tests that represent kidney disease to a degree, the stepwise regression analysis showed that only hemoglobin significantly contributed to the cognitive control deficits in ESRD patients. Mediation analysis proved that the relationship between hemoglobin and cognitive control deficits of ESRD patients was mediated by WM microstructural alteration of the cingulum. Our results indicated that the anterior cingulum was correlated with cognitive control deficits and mediated the impact of hemoglobin on cognitive control.
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