ArticlePediatric pulmonology2018
Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants.
Article in Pediatric pulmonology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Randomized trial of azithromycin to eradicate Ureaplasma respiratory colonization in preterm infants: 2-year outcomes.Pediatric research · 2022Trial
- Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials comparing transpyloric and gastric feeding.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Neonatal Outcomes Associated with Maternal-Factor-Related Diagnoses: Real-World Evidence from a National Inpatient Database (2010-2025).Medical sciences (Basel, Switzerland) · 2026Article
- Article
- Machine learning predictive models for grading bronchopulmonary dysplasia: umbilical cord blood IL-6 as a biomarker.Frontiers in pediatrics · 2023Article
- Model-Base Estimation of Non-Invasive Ventilation Weaning of Preterm Infants Exposed to Osteopathic Manipulative Treatment: A Propensity-Score-Matched Cohort Study.Healthcare (Basel, Switzerland) · 2022Article
- Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia.Seminars in perinatology · 2022Review
- Early neurodevelopmental follow-up in the NICHD neonatal research network: Advancing neonatal care and outcomes, opportunities for the future.Seminars in perinatology · 2022Article
- Long-term neurodevelopmental outcome in preterm infants with intraventricular haemorrhage.Journal of paediatrics and child health · 2022Article
- Article
- Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Definitions of bronchopulmonary dysplasia and long-term outcomes of extremely preterm infants in Korean Neonatal Network.Scientific reports · 2021Article
- A Review on Non-invasive Respiratory Support for Management of Respiratory Distress in Extremely Preterm Infants.Frontiers in pediatrics · 2020Review
- Application of Neurally Adjusted Ventilatory Assist in Premature Neonates Less Than 1,500 Grams With Established or Evolving Bronchopulmonary Dysplasia.Frontiers in pediatrics · 2020Article
- The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants. An Evidence-based Approach.American journal of respiratory and critical care medicine · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectivesThis study tested the hypothesis that longer duration of any type of respiratory support is associated with an increased rate of death or neurodevelopmental impairment (NDI) at 18-22 months.
methodsRetrospective cohort study using the Generic Database of NICHD Neonatal Research Network from 2006 to 2010. Infants were born at <27 weeks gestational age with birth weights of 401-1000 g. Respiratory support received during initial hospitalization from birth was characterized as follows: no support, only invasive support, only non-invasive support or mixed invasive, and non-invasive support. The primary outcome was death after 24 h of life or NDI at 18-22 months corrected age.
resultsIn a cohort of 3651 infants, 1494 (40.9%) died or had NDI. Cumulative respiratory support of any type beyond 60 days was associated with the likelihood of death or NDI. Infants who only received invasive support had the highest rate (89.1%), followed by those received mixed support (26.1%). Infants who received only non-invasive support had the lowest rate (7.7%). When compared to the only non-invasive support group, both invasive [OR 62.7 (95%CI 25.7, 152.6)] and mixed [OR 6.1 (95%CI 2.6, 14.4)] support groups were significantly more likely to die or have NDI.
conclusionProlonged respiratory support, whether invasive or non-invasive, is associated with increased odds of a poor outcome. The proportion of infants with a poor outcome increased in a dose dependent manner by two factors: the cumulative duration of respiratory support beyond 60 days, and the extent to which invasive support is provided.
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