Evidence map›Paper›PMID 30062712›Full record

ArticleJournal of tissue engineering and regenerative medicine2018

Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes.

Felipe Monte, Tugba Cebe, Daniel Ripperger, Fareed Ighani, Hristo V Kojouharov, Benito M Chen, Harry K W Kim, Pranesh B Aswath, Venu G Varanasi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Felipe MonteDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.ORCID 0000-0001-9775-3612
Tugba CebeDepartment of Materials Science and Engineering, University of Texas at Arlington, Arlington, Texas, USA.
Daniel RippergerTexas A&M University College of Dentistry, Dallas, Texas, USA.
Fareed IghaniTexas A&M University College of Dentistry, Dallas, Texas, USA.
Hristo V KojouharovDepartment of Mathematics, University of Texas at Arlington, Arlington, Texas, USA.
Benito M ChenDepartment of Mathematics, University of Texas at Arlington, Arlington, Texas, USA.
Harry K W KimCenter for Excellence in Hip Disorders, Texas Scottish Rite Hospital, Dallas, Texas, USA.
Pranesh B AswathDepartment of Materials Science and Engineering, University of Texas at Arlington, Arlington, Texas, USA.
Venu G VaranasiDepartment of Materials Science and Engineering, University of Texas at Arlington, Arlington, Texas, USA.
The University of Texas at Arlington · USTexas A&M University · USScottish Rite Hospital · US

Funding

Improving Biomaterials from a Cellular Point of ViewK25DE018230 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VARANASI, VENU GOPAL · 2007 to 2011
$575k
Silicon, a Novel Antioxidant Role in Bone HealingR03DE023872 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI VARANASI, VENU GOPAL · 2014 to 2015
$229k
NIDCR NIH HHS K25 DE018230NIDCR NIH HHS R03 DE023872
6 · The paper itself

Abstract

Oxidative stress, induced by harmful levels of reactive oxygen species, is a common occurrence that impairs proper bone defect vascular healing through the impairment of endothelial cell function. Ionic silicon released from silica-based biomaterials, can upregulate hypoxia-inducible factor-1α (HIF-1α). Yet it is unclear whether ionic Si can restore endothelial cell function under oxidative stress conditions. Therefore, we hypothesized that ionic silicon can help improve human umbilical vein endothelial cells' (HUVECs') survival under toxic oxidative stress. In this study, we evaluated the ionic jsilicon effect on HUVECs viability, proliferation, migration, gene expression, and capillary tube formation under normal conditions and under harmful hydrogen peroxide levels. We demonstrated that 0.5-mM Si

Indexed as

Biocompatible MaterialsSilicatesApoptosisGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideIntracellular Signaling Peptides and ProteinsMitochondrial ProteinsNeoplasm ProteinsNeovascularization, PhysiologicNitric Oxide SynthaseOxidative StressOxidoreductasesSiliconVascular Endothelial Growth Factor ABiocompatible MaterialsHIGD1A protein, humanHydrogen PeroxideIntracellular Signaling Peptides and ProteinsKDR protein, humanMitochondrial ProteinsNeoplasm ProteinsNitric Oxide SynthaseOxidoreductasesSilicatesSiliconsodium metasilicateVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2angiogenesisangiogenic markersantioxidant enzymescell survivalendothelial cellsionic siliconoxidative stress

Identifiers

PMID30062712
PMCPMC6508967
OpenAlexW2885682512

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.