ArticleJournal of nephrology2019
Germline mosaicism is a pitfall in the diagnosis of "sporadic" X-linked Alport syndrome.
Article in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Unveiling Maternal Germline Mosaicism in X-Linked Alport Syndrome by Advanced Genetic Testing.The American journal of case reports · 2025Article
- Genetic analysis of a female patient with X-linked lymphoproliferative disease type 2: a case report.Journal of medical case reports · 2025Article
- Detection of Very Low-Level Somatic MosaicFrontiers in medicine · 2022Article
- Detection of Mosaic Variants in Mothers of MPS II Patients by Next Generation Sequencing.Frontiers in molecular biosciences · 2021Article
- The First Case Report of X-Linked Sideroblastic Anemia With Ataxia of Chinese Origin and Literature Review.Frontiers in pediatrics · 2021Article
- Low frequency of parental mosaicism in de novo COL4A5 mutations in X-linked Alport syndrome.Molecular genetics & genomic medicine · 2020Article
- Identification of paternal germline mosaicism by MicroSeq and targeted next-generation sequencing.Molecular genetics & genomic medicine · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
Approximately 80% of patients with Alport syndrome have X-linked Alport syndrome (XLAS), which is caused by mutations in the type IV collagen alpha 5 gene (COL4A5). In patients with XLAS, approximately 10-15% of COL4A5 mutations occur as spontaneous events. Here, we describe maternal germline mosaicism in a family of XLAS patients. Since our patient's parents showed normal urinary findings without COL4A5 mutation using genomic DNA isolated from peripheral leukocytes, the patient was initially diagnosed with "sporadic" XLAS. However, genetic analysis of the patient's sister with microscopic hematuria identified the same COL4A5 heterozygous mutation. Therefore, we concluded that our patient and the sister had XLAS caused by maternal germline mosaicism, not "sporadic" XLAS. Our case suggests that "sporadic" XLAS may in some patients be caused by the transmission of an abnormal allele from either parent with germline mosaicism in COL4A5. Germline mosaicism is thought to be rare, but we should consider that even asymptomatic parents of "sporadic" XLAS patients could carry a somatic and/or germline mosaicism. More cautious genetic counseling is advisable for all "sporadic" XLAS patients. Furthermore, urinalysis screening of "sporadic" XLAS patients' siblings is also important to enable an earlier detection of parental germline mosaicism.
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