Evidence map›Paper›PMID 30062418›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.

Benjamin Mizukawa, Eric O'Brien, James C Mulloy, Yi Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Benjamin MizukawaCancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Eric O'BrienCancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
James C MulloyCancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Yi ZhengCancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA. yi.zheng@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · US

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Pediatric Center--Gene Expression /Developmental ScienceK12HD028827 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Tina Lee Cheng · 2002 to 2026
$9.6M
Leukemia stem cell polarity and differentiation therapyR01CA204895 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI MULLOY, JAMES C, ZHENG, YI · 2017 to 2021
$2.2M
Targeting Cdc42 for bone marrow transplant therapiesR01CA193350 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI ZHENG, YI · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA193350NCI NIH HHS R01 CA204895NICHD NIH HHS K12 HD000850NICHD NIH HHS K12 HD028827
6 · The paper itself

Abstract

Cdc42 was originally discovered as a key regulator of bud site assembly and polarity in S. cerevisiae. Recent genetic studies have shown that the function of Cdc42 in regulating cell polarity appears highly conserved from budding yeast to humans. The role of Cdc42 in hematopoietic cell transformation and leukemia progression has been studied in an acute myeloid leukemia model using the MLL-AF9 oncogene-induced transformation and a Cdc42 conditional gene-targeted mouse model. Here we describe the leukemia cell polarity and division symmetry assays in the context of leukemia cell fate determination.

Indexed as

Cell DivisionCell PolarityAnimalscdc42 GTP-Binding Proteincdc42 GTP-Binding Protein, Saccharomyces cerevisiaeCell Transformation, NeoplasticHematopoietic Stem CellsHomeodomain ProteinsHumansLeukemia, Myeloid, AcuteMiceNeoplasms, ExperimentalNuclear ProteinsOncogene Proteins, FusionSaccharomyces cerevisiaecdc42 GTP-Binding Proteincdc42 GTP-Binding Protein, Saccharomyces cerevisiaeCdc42 protein, mouseHomeodomain ProteinsMixl1 protein, mouseMllt3 protein, mouseNuclear ProteinsOncogene Proteins, FusionCell fateCell polarityDifferentiationDivision symmetrySelf-renewal

Identifiers

PMID30062418
PMCPMC6457108
OpenAlexW2886678035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.