ArticleJACC. Basic to translational science2018
In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer,
Open access · goldAbstract read
In one paragraph
Article in JACC. Basic to translational science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis.Molecular diagnosis & therapy · 2022Pooled it
- Molecular imaging of atherosclerotic plaque vulnerability: a narrative review.The international journal of cardiovascular imaging · 2026Review
- The Pro-Metastatic Roles of ROS.Antioxidants (Basel, Switzerland) · 2026Review
- A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications.Molecular oncology · 2025Review
- Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity.Frontiers in aging · 2025Review
- The implication of aberrant NRF2 activation in management of female cancers.Frontiers in oncology · 2025Review
- The oxygen puzzle in FLASH radiotherapy: A comprehensive review and experimental outlook.Clinical and translational radiation oncology · 2024Review
- Innovations in Nuclear Medicine Imaging for Reactive Oxygen Species: Applications and Radiopharmaceuticals.Antioxidants (Basel, Switzerland) · 2024Review
- Sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents ejection fraction reduction, reduces myocardial and renal NF-κB expression and systemic pro-inflammatory biomarkers in models of short-term doxorubicin cardiotoxicity.Frontiers in cardiovascular medicine · 2024Article
- Cardiac Toxicities in Oncology: Elucidating the Dark Box in the Era of Precision Medicine.Current issues in molecular biology · 2023Review
- Tales from the future-nuclear cardio-oncology, from prediction to diagnosis and monitoring.European heart journal. Cardiovascular Imaging · 2023Review
- The Role of Advanced Cardiovascular Imaging Modalities in Cardio-Oncology: From Early Detection to Unravelling Mechanisms of Cardiotoxicity.Journal of clinical medicine · 2023Review
- Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies.Seminars in nuclear medicine · 2023Review
- Nuclear medicine in the assessment and prevention of cancer therapy-related cardiotoxicity: prospects and proposal of use by the European Association of Nuclear Medicine (EANM).European journal of nuclear medicine and molecular imaging · 2023Article
- [Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Biomedical Imaging in Experimental Models of Cardiovascular Disease.Circulation research · 2022Review
- Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo.Nature metabolism · 2022Review
- Detecting Validated Intracellular ROS Generation withMolecular imaging and biology · 2022Article
- Molecular imaging of free radicals for anthracycline-induced cardiotoxicity: See the burn?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Feasibility study of PET dynamic imaging of [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Nabil E BoutagySection of Cardiovascular Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale School of Medicine, New Haven, Connecticut.
Jing WuDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Zhengxi CaiDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Wenjie ZhangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Carmen J BoothSection of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut.
Tassos C KyriakidesYale School of Public Health (Biostatistics), Yale School of Medicine, New Haven, Connecticut.
Daniel PfauSection of Cardiovascular Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale School of Medicine, New Haven, Connecticut.
Tim MulnixDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Zhao LiuSection of Cardiovascular Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale School of Medicine, New Haven, Connecticut.
Edward J MillerSection of Cardiovascular Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale School of Medicine, New Haven, Connecticut.
Lawrence H YoungSection of Cardiovascular Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale School of Medicine, New Haven, Connecticut.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Chi LiuDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Albert J SinusasSection of Cardiovascular Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale School of Medicine, New Haven, Connecticut.
Yale University · USImaging Center · USSichuan University · CN
Funding
Training In Multi-modality Molecular & Translational Cardiovascular ImagingT32HL098069 · NHLBI · YALE UNIVERSITY · PI JAMES S DUNCAN, Georges El Fakhri · 2010 to 2026
$5.2MLow-dose SPECT/CT for imaging chemotherapy-induced microvascular cardiotoxicityR01HL123949 · NHLBI · YALE UNIVERSITY · PI LIU, CHI · 2014 to 2018
$3.2MMolecular Imaging Predicts Atrial Remodeling and Fibrillation VulnerabilityR01HL113352 · NHLBI · YALE UNIVERSITY · PI AKAR, JOSEPH GABRIEL, SINUSAS, ALBERT J · 2013 to 2016
$2.8MState-of-the-Art Small Animal PET/CT InstrumentationS10OD010322 · OD · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2013 to 2013
$595kNHLBI NIH HHS R01 HL113352NHLBI NIH HHS R01 HL123949NHLBI NIH HHS T32 HL098069NIH HHS S10 OD010322
Abstract
Reactive oxygen species (ROS) are involved in doxorubicin-induced cardiotoxicity. The authors investigated the efficacy of
Indexed as
2D, 2-dimensionalcardiotoxicityCT, computed tomographyDOX, doxorubicin HCldoxorubicinH&E, hematoxylin and eosinLVEF, left ventricular ejection fractionLV, left ventricle/ventricularMMP, matrix metalloproteinaseMT, Masson’s trichromePET, positron emission tomographypositron emission tomographyreactive oxygen speciesROS, reactive oxygen speciesSUV, standardized uptake valueTUNEL, terminal deoxynucleotidyl transferase-mediated nick-end labelingVOI, volume of interest
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.