ArticleJACC. Basic to translational science2018
Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.
Article in JACC. Basic to translational science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Associations Between Acute Heat Exposure and Hospitalization for Takotsubo Syndrome in the State of California, 2006 to 2019.Journal of the American Heart Association · 2026Article
- Takotsubo Syndrome: The First Non-Acute Proteomic Analysis by Remote Dried Blood Microsampling.Journal of cardiovascular translational research · 2026Article
- Antenatal melatonin for cardiovascular deficits in fetal growth restriction.The Journal of physiology · 2026Article
- The Genetic Puzzle of the Stress-Induced Cardiomyopathy (Takotsubo Syndrome): State of Art and Future Perspectives.Biomolecules · 2025Review
- Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives.Antioxidants (Basel, Switzerland) · 2025Review
- Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score.ESC heart failure · 2025Article
- Development of a small animal model replicating core characteristics of takotsubo syndrome in humans.European heart journal open · 2024Article
- Hypoxia-Induced Pulmonary Injury-Adrenergic Blockade Attenuates Nitrosative Stress, and Proinflammatory Cytokines but Not Pulmonary Edema.Journal of cardiovascular development and disease · 2024Article
- Animal models of Takotsubo syndrome: bridging the gap to the human condition.Frontiers in cardiovascular medicine · 2024Review
- Inflammatory Forms of Cardiomyocyte Cell Death in the Rat Model of Isoprenaline-Induced Takotsubo Syndrome.Biomedicines · 2023Article
- Triggers, characteristics, and hospital outcome of patients with Takotsubo syndrome: 10 years experience in a large university hospital centre.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Refining the reproducibility of a murine model of stress-induced reversible cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2023Article
- The Immunology of Takotsubo Syndrome.Frontiers in immunology · 2023Review
- Takotsubo Syndrome: The Secret Crosstalk between Heart and Brain.Reviews in cardiovascular medicine · 2023Review
- Can takotsubo syndrome be rapidly diagnosed in the emergency department? A case study.SAGE open medical case reports · 2023Article
- Molecular Mechanisms of Takotsubo Syndrome.International journal of molecular sciences · 2022Review
- Coronavirus Disease 2019 and Takotsubo Syndrome.Reviews in cardiovascular medicine · 2022Review
- Metabolic alterations in a rat model of takotsubo syndrome.Cardiovascular research · 2022Article
- TakoTsubo Syndrome: First an Acute Coronary Vasculitis and Then Prolonged Myocarditis?Reviews in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.