Evidence map›Paper›PMID 30062172›Full record

ArticleJACC. Basic to translational science2017

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs.

Jeong Shim, Christian Bo Poulsen, Mette K Hagensen, Torben Larsen, Peter M H Heegaard, Christina Christoffersen, Lars Bolund, Mette Schmidt, Ying Liu, Juan Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Pig and Mouse Models of Hyperlipidemia and Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  3. Apolipoprotein E and Atherosclerosis.Current atherosclerosis reports · 2021
    Review
  4. Article
  5. Modelling of atherosclerosis in genetically modified animals.American journal of translational research · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jeong ShimDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Christian Bo PoulsenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mette K HagensenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Torben LarsenDepartment of Animal Science, Aarhus University, Aarhus, Denmark.
Peter M H HeegaardNational Veterinary Institute, Technical University of Denmark, Lyngby, Denmark.
Christina ChristoffersenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Lars BolundDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Mette SchmidtSection for Veterinary Reproduction and Obstetrics, Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ying LiuDepartment of Animal Science, Aarhus University, Aarhus, Denmark.
Juan LiDepartment of Animal Science, Aarhus University, Aarhus, Denmark.
Rong LiDepartment of Animal Science, Aarhus University, Aarhus, Denmark.
Henrik CallesenDepartment of Animal Science, Aarhus University, Aarhus, Denmark.
Jacob F BentzonDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Charlotte B SørensenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study,

Indexed as

APOB, apolipoprotein BAPOE, apolipoprotein Eapolipoprotein EatherosclerosiscDNA, complementary DNAHFHC, high-fat high-cholesterolIDL, intermediate-density lipoproteinLAD, left anterior descending (coronary artery)LDL, low-density lipoproteinLDLR, low-density lipoprotein receptorLF, low-fatNeo, neomycinpigrAAV, recombinant adeno-associated virusremnant cholesterol dysbetalipoproteinemiaSMC, smooth muscle cellVLDL, very-low-density lipoprotein

Identifiers

PMID30062172
PMCPMC6058916

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.