Evidence map›Paper›PMID 30062171›Full record

ArticleJACC. Basic to translational science2017

Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk.

Vesna Nikolova-Krstevski, Soeren Wagner, Ze Yan Yu, Charles D Cox, Jasmina Cvetkovska, Adam P Hill, Inken G Huttner, Victoria Benson, Andreas A Werdich, Calum MacRae and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Calcium and Heart Failure: How Did We Get Here and Where Are We Going?International journal of molecular sciences · 2021
    Review
  11. How TRPC Channels Modulate Hippocampal Function.International journal of molecular sciences · 2020
    Review
  12. Review
  13. Review
  14. Article
  15. Transmembrane insertases andThe Journal of biological chemistry · 2019
    Article
  16. TRP Channels Mediated Pathological CaFrontiers in cardiovascular medicine · 2019
    Review
  17. Frontiers in bioengineering and biotechnology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Vesna Nikolova-KrstevskiMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Soeren WagnerDepartment of Anesthesiology, University Clinic Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Ze Yan YuSt. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.
Charles D CoxMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Jasmina CvetkovskaMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Adam P HillMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Inken G HuttnerMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Victoria BensonDepartment of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Andreas A WerdichCardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Calum MacRaeCardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Michael P FeneleySt. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.
Oliver FriedrichMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Boris MartinacMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Diane FatkinMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Victor Chang Cardiac Research Institute · AUUNSW Sydney · AUBrigham and Women's Hospital · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHarvard University · USSt Vincent's Clinic · AUUniversity of Auckland · NZ

Funding

Molecular Mechanisms of Stretch-Induced Electrical Remodeling in the HeartR00HL112724 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WERDICH, ANDREAS AUGUSTINUS · 2015 to 2018
$747k
Molecular Mechanisms of Stretch-Induced Electrical Remodeling in the HeartK99HL112724 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WERDICH, ANDREAS AUGUSTINUS · 2012 to 2013
$265k
NHLBI NIH HHS K99 HL112724NHLBI NIH HHS R00 HL112724
6 · The paper itself

Abstract

Mechanoelectrical feedback may increase arrhythmia susceptibility, but the molecular mechanisms are incompletely understood. This study showed that mechanical stretch altered the localization, protein levels, and function of the cation-selective transient receptor potential channel (TRPC)-6 in atrial endocardial cells in humans, pigs, and mice. In endocardial/myocardial cross-talk studies, addition of media from porcine atrial endocardium (AE) cells altered the calcium (Ca

Indexed as

Ab, antibodyAE, atrial endocardiumAF, atrial fibrillationAPB, aminoethoxydiphenyl borateatrial endocardiumCa2+, calcium[Ca2+]i, intracellular global Ca2+CM, cardiomyocyteDil-Ac-LDL, dil acetylated−low-density lipoproteinendotheliumET, endothelinHUVEC, human umbilical vein endothelial celliPS, induced pluripotent stemmechanical stretchOAG, 1-oleoyl-2-acetyl-sn-glycerolTAC, thoracic aortic constrictionTet, tetanus toxintransient receptor potential channelsTRPC, transient receptor potential channel

Identifiers

PMID30062171
PMCPMC6058914
OpenAlexW2766329321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.