Evidence map›Paper›PMID 30062157›Full record

ArticleJACC. Basic to translational science2017

Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification.

Bin Yu, Anouar Hafiane, George Thanassoulis, Leah Ott, Nial Filwood, Marta Cerruti, Ophélie Gourgas, Dominique Shum-Tim, Hamood Al Kindi, Benoit de Varennes and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
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  6. Review
  7. Review
  8. The biology of lipoprotein(a): From genetics to molecular mechanisms.European journal of clinical investigation · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Novel Circulating Biomarkers in Aortic Valve Stenosis.International journal of molecular sciences · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Bin YuDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Anouar HafianeDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
George ThanassoulisDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Leah OttDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Nial FilwoodDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Marta CerrutiDepartment of Materials Engineering, McGill University, Montreal, Quebec, Canada.
Ophélie GourgasDepartment of Materials Engineering, McGill University, Montreal, Quebec, Canada.
Dominique Shum-TimDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Hamood Al KindiDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Benoit de VarennesDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Alawi Alsheikh-AliCollege of Medicine, Mohammed Bin Rashid University of Medical and Health Sciences, Dubai, United Arab Emirates.
Jacques GenestDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
Adel SchwertaniDivisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.
McGill University · CAMohammed Bin Rashid University of Medicine and Health Sciences · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expression of chondro-osteogenic mediators; and decreased SOX9 and matrix Gla protein (p < 0.001). Inhibition of MAPK38 and GSK3β significantly reduced Lp(a)-induced calcification of human aortic valve interstitial cells (p < 0.001). There was abundant presence of Lp(a) and E06 immunoreactivity in diseased human aortic valves. The present study demonstrates a causal effect for Lp(a) in aortic valve calcification and suggests that interfering with the Lp(a)pathway could provide a novel therapeutic approach in the management of this debilitating disease.

Indexed as

ALP, alkaline phosphataseapo(a), apolipoprotein(a)BMP, bone morphogenetic proteinFWHM, full width half maximumHAVIC, human aortic valve interstitial cellLDL, low-density lipoproteinLOX-1, oxidized LDL receptor 1Lp(a), lipoprotein(a)MAPK, mitogen-activated protein kinaseMGP, matrix Gla proteinmRNA, messenger ribonucleic acidoxidized phospholipidsOxPL, oxidized phospholipidRaman spectroscopyreal-time PCRstenosis

Identifiers

PMID30062157
PMCPMC6034440
OpenAlexW2747401552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.