Evidence map›Paper›PMID 30062135›Full record

ArticleLaryngoscope investigative otolaryngology2018

Otogenic brain abscesses: A systematic review.

Maria J Duarte, Elliott D Kozin, Miriam B Barshak, Katherine Reinshagen, Renata M Knoll, Kalil G Abdullah, D Bradley Welling, David H Jung

Abstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. [Multidisciplinary diagnosis and treatment of temporal bone cholesteatoma complicated with brain abscess].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  5. Article
  6. Article
  7. Foreign Contaminants Target Brain Health.CNS & neurological disorders drug targets · 2025
    Review
  8. Article
  9. [Clinical analysis of cases of otogenic sigmoid sinus thrombosis in children].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  10. Article
  11. Article
  12. [Clinical analysis of 11 cases of otogenic intracranial complications treated by multidisciplinary collaboration].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Cholesteatoma Classification: Review of Literature and Proposed Indian Classification System-TAMPFIC.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Brain abscess in pediatric age: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria J DuarteDepartment of Otolaryngology, Harvard Medical School Boston Massachusetts U.S.A.
Elliott D KozinDepartment of Otolaryngology, Harvard Medical School Boston Massachusetts U.S.A.ORCID 0000-0002-0305-0682
Miriam B BarshakMassachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A.
Katherine ReinshagenMassachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A.
Renata M KnollMassachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A.
Kalil G AbdullahDepartment of Neurosurgery Hospital of the University of Pennsylvania Philadelphia Pennsylvania U.S.A.
D Bradley WellingDepartment of Otolaryngology, Harvard Medical School Boston Massachusetts U.S.A.
David H JungDepartment of Otolaryngology, Harvard Medical School Boston Massachusetts U.S.A.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOtogenic brain abscesses are one of the most significant life-threatening complications of otologic infections. Given their low prevalence, otogenic brain abscesses require a high index of suspicion for diagnosis. In this systematic review, we aim to provide an analysis of otogenic brain abscesses and describe common clinical signs and symptoms, bacteriology, location, treatment options, morbidity, and mortality. DATA SOURCES: PubMed, Cochrane CENTRAL database, Google Scholar, and Scopus.

methodsA systematic review of literature was performed using the Preferred Reporting Items for Systematic Reviews and Meta-analyses recommendations. Variables assessed included clinical signs and symptoms, bacteriology, location, treatment, morbidity, and mortality.

resultsTwenty-nine studies met inclusion and exclusion criteria, corresponding to a total of 1307 otogenic abscess cases for review. Fifty-five percent of abscesses were found in the temporal lobe and 28% in the cerebellum. Most patients (88.3%) had a history of suppurative chronic otitis media. The most common symptoms were headache, altered mental status, papilledema, and meningeal irritation. Fever, nausea, and vomiting affected about 40% of patients. The most commonly cultured bacterial species was

conclusionAlthough rare, otogenic brain abscesses may occur as a complication of suppurative otitis media and require a high index of suspicion. Appropriate imaging studies and multidisciplinary expertise are crucial in the diagnosis and management. LEVEL OF EVIDENCE: 4.

Indexed as

Brain abscesscomputed tomographymagnetic resonance imagingotologic infection

Identifiers

PMID30062135
PMCPMC6057212

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.