Evidence map›Paper›PMID 30062052›Full record

ArticleCell death discovery2018

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative

Arjun Balakrishnan, Rajendra Karki, Brent Berwin, Masahiro Yamamoto, Thirumala-Devi Kanneganti

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cell death discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Engineering low-endotoxin lipid A in a double auxotrophFrontiers in cellular and infection microbiology · 2026
    Article
  4. Advances inMicroorganisms · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Evidence for intracellularJournal of bacteriology · 2024
    Review
  11. NLRP inflammasomes in health and disease.Molecular biomedicine · 2024
    Review
  12. Article
  13. Article
  14. Pseudomonas-dominant microbiome elicits sustained IL-1β upregulation in alveolar macrophages from lung transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023
    Article
  15. Gasdermin D kills bacteria.Microbiological research · 2023
    Review
  16. Cells · 2023
    Review
  17. A truncated mutation of MucA inActa biochimica et biophysica Sinica · 2022
    Article
  18. Pyroptosis in inflammation-related respiratory disease.Journal of physiology and biochemistry · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Arjun Balakrishnan1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105 USA.
Rajendra Karki1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105 USA.
Brent Berwin2Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756 USA.
Masahiro Yamamoto3Department of Immunoparasitology, Research Institute for Microbial Diseases, Laboratory of Immunoparasitology, World Premier International Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871 Japan.
Thirumala-Devi Kanneganti1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105 USA.
St. Jude Children's Research Hospital · USDartmouth College · USOsaka University · JP

Funding

Role of NLR Inflammasomes in Autoinflammatory Diseases and Host DefenseR01AR056296 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2008 to 2022
$5.9M
The Non-Inflammasome NLRs in Immunity and Host defenseR01AI124346 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2016 to 2026
$5.8M
Inflammatory Caspases in Innate Immunity and InflammationR37AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2017 to 2026
$4.9M
NLR signaling in colitis and colorectal tumorigenesisR01CA163507 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2020
$3.5M
Inflammatory Caspases in Innate Immunity and InflammationR01AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2016
$2.2M
NCI NIH HHS R01 CA163507NIAID NIH HHS R01 AI101935NIAID NIH HHS R01 AI124346NIAID NIH HHS R37 AI101935NIAMS NIH HHS R01 AR056296
6 · The paper itself

Abstract

Detection of bacterial ligands is a pre-requisite for inflammasome activation. During

Identifiers

PMID30062052
PMCPMC6060091
OpenAlexW2809736937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.