Evidence map›Paper›PMID 30061959›Full record

ArticleThe Pan African medical journal2018

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia.

Doris Kafita, Trevor Kaile, Evans Malyangu, Rabecca Tembo, Ephraim Zulu, Chrispin Chisanga, Annie Kalonda, Mulemba Samutela, Pascal Polepole, Geoffrey Kwenda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pan African medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Doris KafitaDepartment of Biomedical Sciences, School of Medicine, University of Zambia, Lusaka, Zambia.
Trevor KaileDepartment of Pathology and Microbiology, School of Medicine, University of Zambia, Lusaka, Zambia.
Evans MalyanguDepartment of Pathology, Maina Soko Military Hospital, Lusaka, Zambia.
Rabecca TemboDepartment of Pathology and Microbiology, School of Medicine, University of Zambia, Lusaka, Zambia.
Ephraim ZuluDepartment of Biomedical Sciences, School of Medicine, University of Zambia, Lusaka, Zambia.
Chrispin ChisangaDepartment of Biomedical Sciences, School of Medicine, University of Zambia, Lusaka, Zambia.
Annie KalondaDepartment of Biomedical Sciences, School of Medicine, University of Zambia, Lusaka, Zambia.
Mulemba SamutelaDepartment of Biomedical Sciences, School of Medicine, University of Zambia, Lusaka, Zambia.
Pascal PolepoleDepartment of Biomedical Sciences, School of Medicine, University of Zambia, Lusaka, Zambia.
Geoffrey KwendaDepartment of Biomedical Sciences, School of Medicine, University of Zambia, Lusaka, Zambia.
University of Zambia · ZM

Funding

Programmatic: Expanding Innovative Multidisciplinary Medical Education in ZambiaR24TW008873 · FIC · UNIVERSITY OF ZAMBIA · PI MULLA, YAKUB F · 2010 to 2015
$9.0M
FIC NIH HHS R24 TW008873
6 · The paper itself

Abstract

introductionEpstein-Barr virus (EBV) is a ubiquitous virus that infects more than 90% of the world's population, and is implicated in lymphoma pathogenesis. However, in Zambia during the diagnosis of these lymphomas, the association of the virus with the lymphomas is not established. Since most patients with lymphomas have poor prognosis, the identification of the virus within the lymphoma lesion will allow for more targeted therapy. The aim of this study was to provide evidence of the presence of the EBV in lymphomas diagnosed at the University Teaching Hospital (UTH) in Lusaka, Zambia.

methodsOne hundred and fifty archival formalin-fixed paraffin embedded suspected lymphoma tissues stored over a 4-year period in the Histopathology Laboratory at the UTH in Lusaka, Zambia, were analysed. Histological methods were used to identify the lymphomas, and the virus was detected using Polymerase Chain Reaction (PCR). Subtyping of the virus was achieved through DNA sequencing of the EBNA-2 region of the viral genome. Chi square or fisher's exact test was used to evaluate the association between EBV status, type of lymphoma and gender.

resultsThe majority of the lymphomas identified were non-Hodgkin's lymphoma (NHL) (80%) followed by Hodgkin's lymphoma (HL) (20%). EBV was detected in 51.8% of the cases, 54.5% of which were associated with NHL cases, while 40.9% associated with HL cases. The predominant subtype of the virus in both types of lymphomas was subtype 1. One of the lymphoma cases harboured both subtype 1 and 2 of the virus.

conclusionThis study showed that EBV is closely associated with lymphomas. Therefore, providing evidence of the presence of the virus in lymphoma tissues will aid in targeted therapy. To our knowledge this is the first time such data has been generated in Zambia.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolEpstein-Barr Virus InfectionsFemaleGenome, ViralHerpesvirus 4, HumanHodgkin DiseaseHospitals, UniversityHumansInfantLymphoma, Non-HodgkinMaleEpstein-Barr virusHodgkin´s lymphomaMolecular detectionNon-Hodgkin´s lymphomaZambia

Identifiers

PMID30061959
PMCPMC6061862
OpenAlexW2795073614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.