ReviewFrontiers in endocrinology2018
Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes.
Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
157 citing papers in PubMed, 1 synthesis or guideline pooled it, 306 citations in OpenAlex.
- Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis.Human reproduction update · 2020Pooled it
- Trial
- Inflammatory Status and Glycemic Control Level of Patients with Type 2 Diabetes and Periodontitis: A Randomized Clinical Trial.International journal of environmental research and public health · 2021Trial
- Effects of potato resistant starch intake on insulin sensitivity, related metabolic markers and appetite ratings in men and women at risk for type 2 diabetes: a pilot cross-over randomised controlled trial.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2021Trial
- Transcriptome and experimental validation identify prognostic genes associated with lipotoxicity in thyroid carcinoma.BMC cancer · 2026Article
- Delayed insulin secretion in the early postpartum period is associated with future abnormal glucose metabolism among women with a history of gestational diabetes mellitus: a prospective cohort study.BMC pregnancy and childbirth · 2026Article
- High-Concentration Cyanidin-3-O-Glucoside Attenuates Palmitic Acid-Induced Oxidative Stress via ROS Suppression in Pancreatic β-Cells.Journal of experimental pharmacology · 2026Article
- Evaluation of Serum Antioxidant Activity in Type 2 Diabetes and Prediabetes: Links with Nutritional and Anthropometric Factors-Preliminary Studies.Current issues in molecular biology · 2025Article
- Review
- Knockoff procedure improves susceptibility gene identifications in conditional transcriptome-wide association studies.American journal of human genetics · 2025Article
- A long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin secretion in mice.Science advances · 2025Article
- Fatty acids and physical activity are critical for β-cell mass and insulin sensitivity: Pathways to T2D and prevention.Journal of theoretical biology · 2025Article
- Association between the cardiometabolic index and all-cause and cardiovascular mortality in diabetes and prediabetes.Cardiovascular diagnosis and therapy · 2025Article
- Induction of hyperlipidemic pancreatitis by different fatty acids: A narrative review.World journal of gastroenterology · 2025Review
- miRNA-642a-3p protects β cells from glucolipotoxicity.Molecular therapy. Nucleic acids · 2025Article
- Association of cardiometabolic index with gallstone disease and insulin resistance based on NHANES data.BMC gastroenterology · 2025Article
- Article
- Administration of Trichinella spiralis Antigens Alleviated Diabetic Nephropathy in Diabetic Mice.Acta parasitologica · 2025Article
- Lipotoxicity Induces β-cell Small Extracellular Vesicle-Mediated β-cell Dysfunction in Male Mice.Endocrinology · 2025Article
- Study on the pharmacodynamics and related mechanism of Tangningtongluo tablet on prediabetes mice based on the theory of "liver controlling dispersion".Journal of traditional and complementary medicine · 2025Article
97 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta-cell impairment leads to the development of diabetes. Elevated levels of circulating fatty acids (FAs) and disturbances in lipid metabolism regulation are associated with obesity, and they are major factors influencing the increase in the incidence of type 2 diabetes. Chronic free FA (FFA) treatment induces insulin resistance and beta-cell dysfunction; therefore, reduction of elevated plasma FFA levels might be an important therapeutic target in obesity and type 2 diabetes. Lipid signals via receptors, and intracellular mechanisms are involved in FFA-induced apoptosis. In this paper, we discuss lipid actions in beta cells, including effects on metabolic pathways and stress responses, to help further understand the molecular mechanisms of lipotoxicity-induced type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.