Evidence map›Paper›PMID 30061823›Full record

ArticleFrontiers in aging neuroscience2018

Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood.

Ting Xiao, Sheng Zhang, Lue-En Lee, Herta H Chao, Christopher van Dyck, Chiang-Shan R Li

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Association between vertebral fractures and brain volume: insights from a community cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ting XiaoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Sheng ZhangDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Lue-En LeeDepartment of Psychiatry, National Taiwan University, Taipei, Taiwan.
Herta H ChaoDepartment of Medicine, Yale University School of Medicine, New Haven, CT, United States.
Christopher van DyckDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Chiang-Shan R LiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.

Funding

Cognitive control and cocaine dependence: thalamic noradrenergic processesR01DA023248 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2008 to 2018
$4.0M
Cerebral Correlates of Early Habitual DrinkingR01AA021449 · NIAAA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2013 to 2017
$1.2M
Thalamic cortical dysfunction and predictors of relapse in cocaine dependenceK25DA040032 · NIDA · YALE UNIVERSITY · PI ZHANG, SHENG · 2015 to 2019
$834k
Aging and cerebral regulation of physiological responses to social emotionsR21MH113134 · NIMH · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2017 to 2018
$397k
Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and predictionI01CX001301 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI Herta Huey-An Chao · 2017 to 2026
–
CSRD VA I01 CX001301NIAAA NIH HHS R01 AA021449NIDA NIH HHS K25 DA040032NIDA NIH HHS R01 DA023248NIMH NIH HHS R21 MH113134
6 · The paper itself

Abstract

Functional connectivities of the amygdala support emotional and cognitive processing. Life-span development of resting-state functional connectivities (rsFC) of the amygdala may underlie age-related differences in emotion regulatory mechanisms. To date, age-related changes in amygdala rsFC have been reported through adolescence but not as thoroughly for adulthood. This study investigated age-related differences in amygdala rsFC in 132 young and middle-aged adults (19-55 years). Data processing followed published routines. Overall, amygdala showed positive rsFC with the temporal, sensorimotor and ventromedial prefrontal cortex (vmPFC), insula and lentiform nucleus, and negative rsFC with visual, frontoparietal, and posterior cingulate cortex and caudate head. Amygdala rsFC with the cerebellum was positively correlated with age, and rsFCs with the dorsal medial prefrontal cortex (dmPFC) and somatomotor cortex were negatively correlated with age, at voxel

Indexed as

agingamygdalaemotionfMRIlimbicrsFC

Identifiers

PMID30061823
PMCPMC6055042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.