Evidence map›Paper›PMID 30061757›Full record

ArticleNature microbiology2018

N

Wang Liu, Yan Zhou, Tao Peng, Ping Zhou, Xiaojun Ding, Zilin Li, Haoyu Zhong, Yue Xu, She Chen, Howard C Hang and 1 more

Abstract read
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Pathogen-induced rerouting of host membrane trafficking.Current opinion in cell biology · 2025
    Review
  11. Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  12. Autophagy and Bacterial infections.Autophagy reports · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Chemical Proteomics Reveals NMolecular & cellular proteomics : MCP · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Wang LiuCollege of Life Science, Peking University, Beijing, China.
Yan ZhouNational Institute of Biological Sciences, Beijing, China.
Tao PengSchool of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.
Ping ZhouNational Institute of Biological Sciences, Beijing, China.
Xiaojun DingNational Institute of Biological Sciences, Beijing, China.
Zilin LiNational Institute of Biological Sciences, Beijing, China.
Haoyu ZhongNational Institute of Biological Sciences, Beijing, China.
Yue XuNational Institute of Biological Sciences, Beijing, China.
She ChenNational Institute of Biological Sciences, Beijing, China.
Howard C HangLaboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY, USA. hhang@mail.rockefeller.edu.ORCID http://orcid.org/0000-0003-4053-5547
Feng ShaoNational Institute of Biological Sciences, Beijing, China. shaofeng@nibs.ac.cn.ORCID http://orcid.org/0000-0002-9562-7791
National Institute of Biological Sciences, Beijing · CNPeking University · CNBeijing Normal University · CNRockefeller University · US

Funding

Studies on Protein LipidationR01GM087544 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI HANG, HOWARD C · 2010 to 2023
$4.4M
Distal gut microbiome targets of host anti-proteolytic proteins during colitisR21AI156674 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI HANG, HOWARD C · 2021 to 2022
$488k
NIAID NIH HHS R21 AI156674NIGMS NIH HHS R01 GM087544
6 · The paper itself

Abstract

Shigella flexneri, an intracellular Gram-negative bacterium causative for shigellosis, employs a type III secretion system to deliver virulence effectors into host cells. One such effector, IcsB, is critical for S. flexneri intracellular survival and pathogenesis, but its mechanism of action is unknown. Here, we discover that IcsB is an 18-carbon fatty acyltransferase catalysing lysine N

Indexed as

AcylationAcyltransferasesAmino Acid SequenceCell LineHEK293 CellsHeLa CellsHumansMembrane Proteinsrho GTP-Binding ProteinsSaccharomyces cerevisiaeShigella flexneriSNARE ProteinsType III Secretion SystemsAcyltransferasesMembrane Proteinsrho GTP-Binding ProteinsSNARE ProteinsType III Secretion Systems

Identifiers

PMID30061757
PMCPMC6466622
OpenAlexW2883006823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.