ArticleNature genetics2018
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
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Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 532 papers, 15 of them syntheses that pooled it.
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532citing papers in PubMed, 15 pooled it
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Who cites it
532 citing papers in PubMed, 15 syntheses or guidelines pooled it.
- Genome-Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID-19.Influenza and other respiratory viruses · 2026Pooled it
- Freely available genomic datasets for atrial fibrillation research: current resources and analytical pipeline.Frontiers in genetics · 2026Pooled it
- Genetic susceptibility to uric acid and selected cardiovascular outcomes: a systematic review and meta-analysis of Mendelian randomization studies.Frontiers in endocrinology · 2026Pooled it
- Gut microbiome and atrial fibrillation: mechanistic insights metabolites and comorbidities. Systematic review.Gut microbes · 2025Pooled it
- Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Pooled it
- Genomic data-driven framework for drug target discovery in atrial fibrillation.Journal of translational medicine · 2025Pooled it
- Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies.Journal of cellular and molecular medicine · 2025Pooled it
- Pooled it
- Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.Nature communications · 2025Pooled it
- Rare genetic variants involved in increased risk of paroxysmal atrial fibrillation in a Japanese population.Scientific reports · 2025Pooled it
- Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.Nature genetics · 2025Pooled it
- Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.Nature genetics · 2025Pooled it
- Genetic insights into cardiac conduction disorders from genome-wide association studies.Human genomics · 2025Pooled it
- Identification ofDepression and anxiety · 2025Pooled it
- Mendelian randomization study on insulin resistance and risk of hypertension and cardiovascular disease.Scientific reports · 2024Pooled it
- Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study.European heart journal · 2024Trial
- Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.Renal failure · 2026Article
- Prediction of Atrial Fibrillation Risk Through the Integration of Genetic Information and Artificial Intelligence-Based Electrocardiogram Data.Journal of arrhythmia · 2026Article
- Integrating Genomics and Proteomics to Identify Causal Proteins and Biologic Pathways for Incident Atrial Fibrillation in CKD.Journal of the American Society of Nephrology : JASN · 2026Article
- Genetic links between multimorbidity and human aging.GeroScience · 2026Article
472 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
49 authors.
Jonas B NielsenDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6654-2852
Rosa B ThorolfsdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Lars G FritscheDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2110-1690
Wei ZhouDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Morten W SkovLaboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Sarah E GrahamDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Todd J HerronDepartment of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.
Shane McCarthyRegeneron Genetics Center, Tarrytown, NY, USA.
Ellen M SchmidtDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Gardar SveinbjornssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Ida SurakkaDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Michael R MathisDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Masatoshi YamazakiMedical Device Development and Regulation Research Center, The University of Tokyo, Tokyo, Japan.
Ryan D CrawfordDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Maiken E GabrielsenHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Anne Heidi SkogholtHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Oddgeir L HolmenHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Maoxuan LinDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Brooke N WolfordDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3153-1552
Rounak DeyDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Håvard DalenDepartment of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.ORCID http://orcid.org/0000-0003-1192-3663
Patrick SulemdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7123-6123
Jonathan H ChungRegeneron Genetics Center, Tarrytown, NY, USA.
Joshua D BackmanRegeneron Genetics Center, Tarrytown, NY, USA.
David O ArnardeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.
Colm O'DushlaineRegeneron Genetics Center, Tarrytown, NY, USA.
Anders G HolstLaboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Xiaoquan WenDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Whitney HornsbyDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Frederick E DeweyRegeneron Genetics Center, Tarrytown, NY, USA.
Michael BoehnkeDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Sachin KheterpalDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Bhramar MukherjeeDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Seunggeun LeeDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8097-3878
Hyun M KangDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Hilma HolmdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Jacob KitzmanDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Jordan A ShavitDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2874-4904
José JalifeDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Chad M BrummettDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Tanya M TeslovichRegeneron Genetics Center, Tarrytown, NY, USA.
David J CareyGeisinger Health System, Danville, PA, USA.
Daniel F GudbjartssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Kari StefanssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Gonçalo R AbecasisK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway. goncalo@umich.edu.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. kristian.hveem@ntnu.no.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.ORCID http://orcid.org/0000-0001-5645-4966
Funding
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MUsing genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9MUsing genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MUsing Genetics to Inform Mechanism of Cardiovascular DiseaseR35HL135824 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2017 to 2022
$5.4MDissecting the Genetics of Human Hemostatic Disorders Using ZebrafishR01HL124232 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAVIT, JORDAN A · 2015 to 2019
$1.9MLarge-scale human genetics to understand molecular mechanisms of atrial fibrillation and related traitsR01HL130705 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2016 to 2016
$741kNHGRI NIH HHS T32 HG000040NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL124232NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL130705NHLBI NIH HHS R35 HL135824
Abstract
To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)
Indexed as
Atrial FibrillationBiological Specimen BanksGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHeart Defects, CongenitalHumansMutationRisk
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