ArticleThe ISME journal2018
Astrovirus infections induce age-dependent dysbiosis in gut microbiomes of bats.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 61 citations in OpenAlex.
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- Changes to Skin Microbiome Community Dynamics Support Resistance to Enzootic and Epizootic Strains of Batrachochytrium dendrobatidis (Bd) in the Spotted Salamander (Ambystoma maculatum).Molecular ecology · 2026Article
- Astrovirus infection alters gut microbial communities in a widespread neotropical bat across human-modified landscapes.BMC microbiology · 2026Article
- Virome and Microbiome of Florida Bats Illuminate Viral Co-Infections, Dietary Viral Signals, and Gut Microbiome Shifts.Microorganisms · 2025Article
- Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Journal of virology · 2025Article
- Component specific responses of the microbiomes to common chemical stressors in the human food chain.Environmental microbiome · 2025Article
- Comparative gut microbiome research through the lens of ecology: theoretical considerations and best practices.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Comparative study of gut microbiota reveals the adaptive strategies of gibbons living in suboptimal habitats.NPJ biofilms and microbiomes · 2025Article
- Delayed feeding disrupts diurnal oscillations in the gut microbiome of a neotropical bat in captivity.FEMS microbiology ecology · 2025Article
- Article
- InvasiveInternational journal for parasitology. Parasites and wildlife · 2024Article
- Gut microbiota and healthy longevity.Science China. Life sciences · 2024Review
- Bat species assemblage predicts coronavirus prevalence.Nature communications · 2024Article
- Sex differences and individual variability in the captive Jamaican fruit bat (Artibeus jamaicensis) intestinal microbiome and metabolome.Scientific reports · 2024Article
- Review
- Wildlife gut microbiomes of sympatric generalist species respond differently to anthropogenic landscape disturbances.Animal microbiome · 2023Article
- Fine-scale spatial variation shape fecal microbiome diversity and composition in black-tailed prairie dogs (Cynomys ludovicianus).BMC microbiology · 2023Article
- In sickness and in health: the dynamics of the fruit bat gut microbiota under a bacterial antigen challenge and its association with the immune response.Frontiers in immunology · 2023Article
- The Kitty Microbiome Project: Defining the Healthy Fecal "Core Microbiome" in Pet Domestic Cats.Veterinary sciences · 2022Article
- Infection by a eukaryotic gut parasite in wild Daphnia sp. associates with a distinct bacterial community.FEMS microbiology ecology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astroviruses (AstV) are a major cause of diarrhoea in children. Interestingly, some wildlife species, including bats, remain phenotypically asymptomatic after infection. Disease symptoms, however, may only be less visible in bats and enteric viruses may indeed perturb their gut microbial communities. Gut microbiomes represent an important driver of immune defence mechanisms but potential effects of enteric virus-host microbiome interactions are largely unexplored. Using bats as a natural model system, we show that AstV-infections affect the gut microbiome, with the strength of the effect depending on host age. The gut microbial α- and β-diversity and the predicted microbial functional orthologs decreased in young bats but surprisingly increased in adult AstV + bats. The abundance of bacterial taxa characteristic for healthy microbiomes was strongly reduced in young AstV+ bats, possibly attributable to their immature immune system. Regardless of age, pathogen-containing genera exhibited negative interactions with several commensal taxa and increased after AstV-infection, leading to pathobiont-like shifts in the gut microbiome of all infected bats. Thus, in apparently healthy bats, AstV-infections disturb gut bacterial homeostasis, possibly increasing previously suppressed health risks by promoting co-infections. If similar processes are present in humans, the effects of enteric virus infections might have longer-term impacts extending beyond the directly observed symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.