SynthesisScientific reports2018
Vitamin K supplementation during pregnancy for improving outcomes: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Nutritional supplements and mother's milk composition: a systematic review of interventional studies.International breastfeeding journal · 2021Pooled it
- Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial.BMC women's health · 2022Trial
- Maternal dietary phylloquinone intake (vitamin K1) and early childhood neurodevelopment.Pediatric research · 2026Article
- Therapeutic role of low molecular weight heparin and fat-soluble vitamins in pregnancy-associated prethrombotic conditions.Frontiers in medicine · 2026Review
- Maternal BMI and Diet Quality Modulate Pregnancy Oxidative and Inflammatory Homeostasis.Nutrients · 2025Observational
- Intrahepatic cholestasis of pregnancy.Nature reviews. Disease primers · 2025Review
- Vitamin K Deficiency: Diagnosis and Management.Annals of laboratory medicine · 2025Review
- International expert consensus on micronutrient supplement use during the early life course.BMC pregnancy and childbirth · 2025Article
- Vitamin K and women's health: a review.Frontiers in global women's health · 2025Review
- Advances in Nanomedicine and Biomaterials for Endometrial Regeneration: A Comprehensive Review.International journal of nanomedicine · 2024Review
- Severe Early-Onset Vitamin K Deficiency Bleeding in a Neonate Born to a Mother with Crohn's Disease in Clinical Remission: A Case Report.AJP reports · 2024Article
- Micronutrients in Pregnancy after Bariatric Surgery: A Narrative Review.Journal of clinical medicine · 2023Review
- Vitamin K - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- Gastrointestinal bleeding due to idiopathic early onset of vitamin K deficiency bleeding in a girl baby 50 min after birth: a rare case.BMC pediatrics · 2022Article
- Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences.Nutrition & metabolism · 2022Review
- Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2022Article
- Dietary Intake and Genetic Background Influence Vitamin Needs during Pregnancy.Healthcare (Basel, Switzerland) · 2022Review
- Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide.Therapeutic advances in neurological disorders · 2022Review
- Micronutrient supplementation in pregnancies following bariatric surgery: a practical review for clinicians.Obesity surgery · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study supplementation effect of vitamin K (VK) alone or combined with other nutrients administered to pregnant women, we searched Cochrane Pregnancy and Childbirth Group's Trials Register (till 22 January 2016, updated on 28 February 2018) including other resources. Two review authors independently assessed randomised or quasi-randomised controlled trials for inclusion, data extraction, accuracy, and risk of bias. We included older trials from high-income countries (six; 21,493 women-newborns), judged mostly as high or unclear bias risk. We could not assess high-risk e.g. epileptic women, but healthy women (different gestational ages) received varying VK dosages and duration. We meta-analysed neonatal bleeding (RR 1.16, 95% CI 0.59 to 2.29; P = 0.67) and maternal plasma VK1 (MD 2.46, 95% CI 0.98 to 3.93; P = 0.001). We found many outcomes were un-assessed e.g. perinatal death, maternal bleeding, healthcare utilization. Mostly newborns were included where VK found significantly effective for e.g. serum VK (mother-newborn), maternal breast milk VK. Few trials reported neonatal adverse side effects. The GRADE evidence quality was very low i.e. neonatal bleeding, neonatal jaundice, maternal plasma VK1. The intervention was favourable for maternal sera VK1 but remained uncertain for neonatal bleeding and other outcomes. The existing literature gaps warrant future investigations on un-assessed or inadequately reported outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.