Evidence map›Paper›PMID 30061609›Full record

SynthesisNature communications2018

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Annah B Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N Nguyen, Lies Lahousse, Jeanne C Latourelle, Albert Vernon Smith, Traci M Bartz, Mary F Feitosa and 92 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Article
  11. Circulating proteomic landscape of lung function.The European respiratory journal · 2026
    Article
  12. Smoking drives an epigenetic memory of aberrant hematopoiesis.medRxiv : the preprint server for health sciences · 2026
    Article
  13. Observational
  14. The Developmental Origins of Asthma and COPD.Annual review of physiology · 2026
    Review
  15. Article
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

102 authors.

Annah B WyssEpidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Mi Kyeong LeeEpidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.
Natalie TerzikhanDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, 9000, Belgium.
Jennifer N NguyenCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.
Lies LahousseDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000, CA, The Netherlands.ORCID http://orcid.org/0000-0002-3494-4363
Jeanne C LatourelleDepartment of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA.
Albert Vernon SmithIcelandic Heart Association, Kopavogur, 201, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.
Wei GaoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Tarunveer S AhluwaliaThe Novo Nordisk Foundation Center for Basic Metabolic Research, Metabolic Genetics Section, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Wenbo TangDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.
Christopher OldmeadowHunter Medical Research Institute and Faculty of Health, University of Newcastle, Callaghan, NSW, 2305, Australia.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Kim de JongDepartment of Epidemiologie, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, Netherlands.ORCID http://orcid.org/0000-0002-3948-1046
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.
Xin-Qun WangDivision of Biostatistics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA.
Raymond NoordamDepartment of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Fernando Pires HartwigPostgraduate Program in Epidemiology, Federal University of Pelotas, 96020-220, Pelotas, Brazil.
Victoria E JacksonDepartment of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.
Tianyuan WangIntegrative Bioinformatics Support Group National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.
Ma'en ObeidatThe University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, V6Z 1Y6, Canada.ORCID http://orcid.org/0000-0002-5443-2752
Brian D HobbsChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-9564-0745
Tianxiao HuanThe Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, 20892, USA.
Hongsheng GuiCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, 48202, USA.
Margaret M ParkerChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-6368-5033
Donglei HuSchool of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Lauren S MogilDepartment of Biology, Loyola University Chicago, Chicago, IL, 60660, USA.
Gleb KichaevUniversity of California Los Angeles, Los Angeles, CA, 90095, USA.
Jianping JinWestat, Durham, NC, 27703, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Tamara B HarrisDepartment of Health and Human Services, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Ravi KalhanDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Susan R HeckbertDepartment of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.
Lavinia PaternosterMedical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK.
Kristin M BurkartDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Yongmei LiuWake Forest School of Medicine, Winston-Salem, NC, 27101, USA.
Elizabeth G HollidayHunter Medical Research Institute and Faculty of Health, University of Newcastle, Callaghan, NSW, 2305, Australia.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Judith M VonkDepartment of Epidemiologie, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, Netherlands.
Jason L SandersDepartment of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
R Graham BarrDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Ana Maria Baptista MenezesPostgraduate Program in Epidemiology, Federal University of Pelotas, 96020-220, Pelotas, Brazil.
Hieab H H AdamsDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000, CA, The Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Maarten van den BergeDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, 9700 AB, The Netherlands.
Roby JoehanesHebrew SeniorLife, Harvard University, Boston, MA, 02131, USA.ORCID http://orcid.org/0000-0001-5549-9054
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
Jennifer LibertoSchool of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0003-3326-1680
Lenore J LaunerDepartment of Health and Human Services, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Juan C CeledónDivision of Pulmonary Medicine, Allergy, and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
Stephen B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Rodney J ScottHunter Medical Research Institute and Faculty of Health, University of Newcastle, Callaghan, NSW, 2305, Australia.
Kaare ChristensenDepartment of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, 5000, Denmark.
Jerome I RotterDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Tobias N BontenDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Fernando César WehrmeisterPostgraduate Program in Epidemiology, Federal University of Pelotas, 96020-220, Pelotas, Brazil.
Yohan BosséDepartment of Molecular Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, G1V 4G5, Canada.ORCID http://orcid.org/0000-0002-3067-3711
Shujie XiaoCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, 48202, USA.
Sam OhSchool of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0002-2815-6037
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0001-8509-148X
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Kurt LohmanWake Forest School of Medicine, Winston-Salem, NC, 27101, USA.
Mark McEvoyHunter Medical Research Institute and Faculty of Health, University of Newcastle, Callaghan, NSW, 2305, Australia.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Kent D TaylorDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
David C NickleMerck Research Laboratories, GpGx, Merck & Co., Inc., Kenilworth, NJ, 07033, USA.
L Keoki WilliamsCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, 48202, USA.
Esteban G BurchardSchool of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Heather E WheelerDepartment of Biology, Loyola University Chicago, Chicago, IL, 60660, USA.ORCID http://orcid.org/0000-0001-6955-6021
Don D SinThe University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, V6Z 1Y6, Canada.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, 201, Iceland.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Richard H MyersDepartment of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID http://orcid.org/0000-0002-8365-2674
George O'ConnorNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, 01702, USA.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Metabolic Genetics Section, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, 98195, USA.
Patricia A CassanoDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.
Joohon SungDepartment of Health Science, School of Public Health, Seoul National University, Seoul, 08826, South Korea.
Woo Jin KimDepartment of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 24341, South Korea.
John R AttiaHunter Medical Research Institute and Faculty of Health, University of Newcastle, Callaghan, NSW, 2305, Australia.ORCID http://orcid.org/0000-0001-9800-1308
Leslie LangeUniversity of Colorado Denver, Denver, CO, 80204, USA.
H Marike BoezenDepartment of Epidemiologie, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, Netherlands.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0001-6968-6985
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Bernardo Lessa HortaPostgraduate Program in Epidemiology, Federal University of Pelotas, 96020-220, Pelotas, Brazil.ORCID http://orcid.org/0000-0001-9843-412X
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands.
Hae Kyung ImSection of Genetic Medicine, The University of Chicago, Chicago, IL, 60637, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Guy G BrusselleDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, 9000, Belgium.
Sina A GharibDepartment of Medicine, Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, University of Washington, Seattle, WA, 98109, USA.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.
Stephanie J LondonEpidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA. london2@niehs.nih.gov.ORCID http://orcid.org/0000-0003-4911-5290

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4M
CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
Lung Health Study in the Agricultural Health StudyZIAES102385 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.1M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Genomic and Transcriptomic Analysis of Emphysema and Subclinical ILDR01HL131565 · NHLBI · UNIVERSITY OF VIRGINIA · PI MANICHAIKUL, ANI WANG · 2016 to 2020
$2.0M
NHGRI NIH HHS R15 HG009569NHLBI NIH HHS K08 HL136928NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL131565NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL120393NIA NIH HHS U01 AG023746NIDDK NIH HHS P30 DK020595NIEHS NIH HHS P30 ES009089NIGMS NIH HHS U54 GM115428U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL105756
6 · The paper itself

Abstract

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.

Indexed as

Genome-Wide Association StudyLinkage DisequilibriumPolymorphism, Single NucleotideAsianBlack PeopleFemaleForced Expiratory VolumeGenetic Predisposition to DiseaseGenomicsHispanic or LatinoHumansLungLung DiseasesMalePulmonary Disease, Chronic ObstructiveQuantitative Trait Loci

Identifiers

PMID30061609
PMCPMC6065313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.