ArticleNutrients2018
Design, Development and Construct Validation of the Children's Dietary Inflammatory Index.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309536 (Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES): A Randomized Controlled Trial
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations Between Late Pregnancy Dietary Inflammatory Index (DII) and Offspring Bone Mass: A Meta-Analysis of the Southampton Women's Survey (SWS) and the Avon Longitudinal Study of Parents and Children (ALSPAC).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Pooled it
- Dietary inflammatory potential and oral-periodontal health in children: a cross-sectional study based on the children's dietary inflammatory index dietary inflammatory potential and oral-periodontal health in children.Clinical oral investigations · 2026Observational
- The Association Between Dietary Inflammatory Index with Metabolic Syndrome and Subclinical Atherosclerosis in Children and Adolescents: A Systematic Review.International journal of endocrinology and metabolism · 2026Article
- Dietary Inflammatory Potential and Cardiometabolic Risk Factors in School-Aged Adolescents.Pediatric obesity · 2026Article
- Gut microbiota and western dietary patterns associated with behavioral problems in children and adolescents: a cross-sectional study.Nutrition journal · 2026Article
- Study on the association between dietary inflammatory index and sarcopenia in older adults.BMC geriatrics · 2026Article
- Association between dietary inflammatory potential and cognitive performance in children.European journal of nutrition · 2026Article
- Metal exposures and their interactions with the dietary inflammatory index on inflammatory biomarkers in Mexican adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Association between tooth retention and lower inflammatory dietary pattern in older adults.Frontiers in aging · 2026Article
- Body mass index mediates the association between children's dietary inflammatory index and obstructive sleep apnea-hypopnea syndrome in children: a cross-sectional study.Frontiers in public health · 2026Article
- From nutrient-based to food-based assessment: the evolution of inflammatory indices and their significance for metabolic syndrome and type 3 diabetes mellitus.Frontiers in nutrition · 2026Review
- The impact of dietary inflammation index on benign prostatic hyperplasia: insights from patient data and animal models.Frontiers in nutrition · 2026Article
- The "pro-inflammatory imprint" of ultra-processed food exposure: a review of mechanisms affecting child and adolescent health and development via the gut microbiome-inflammation axis.Frontiers in nutrition · 2026Review
- Association of the children's dietary inflammatory index (c-DII) with thiol/disulfide homeostasis in pediatric glycogen storage disease: a cross-sectional exploratory study.Frontiers in nutrition · 2026Article
- Stress-induced IL-6 regulation in pediatric bone growth disorders: current insights and therapeutic strategies.Frontiers in endocrinology · 2026Review
- Higher Food Inflammation Index Is Linearly Associated With Higher Risk of MASLD: A Cross-Sectional Study Based on the NHANES (1999-2020).Food science & nutrition · 2025Article
- Food inflammation index reveals the key inflammatory components in foods and heterogeneity within food groups: How do we choose food?Journal of advanced research · 2025Article
- Association of Children's Dietary Inflammatory Index with Depression and Anxiety Symptoms in Adolescents: Mediating Role of Inflammation and Cardiometabolic Risk Factors.Alpha psychiatry · 2025Article
- Imbalanced nutrition and increased dietary inflammatory index in children with autism spectrum disorder: associations with neurodevelopmental disorders.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo design and validate a literature-derived, population-based Children's Dietary Inflammatory Index (C-DII)
designThe C-DII was developed based on a review of literature through 2010. Dietary data obtained from children in 16 different countries were used to create a reference database for computing C-DII scores based on consumption of macronutrients, vitamins, minerals, and whole foods. Construct validation was performed using quantile regression to assess the association between C-reactive protein (CRP) concentrations and C-DII scores. DATA SOURCES: All data used for construct validation were obtained from children between six and 14 years of age (
resultsThe C-DII was successfully validated with blood CRP concentrations in this heterogeneous sample of 3300 children from NHANES (52% male; 29% African American, 25% Mexican American; mean age 11 years). The final model was adjusted for sex, age, race, asthma, body mass index (BMI), and infections. Children in level 3 (i.e., quartiles 3 and 4 combined) of the C-DII (i.e., children with the most pro-inflammatory diets) had a CRP value 0.097 mg/dL higher than that in level 1 (i.e., quartile 1) for CRP values at the 75th percentile of CRP using quantile regression (
conclusionThe C-DII predicted blood CRP concentrations among children 6⁻14 years in the NHANES. Further construct validation with CRP and other inflammatory markers is required to deepen understanding of the relationship between the C-DII and markers of inflammation in children.
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