ArticleBMJ open2018
Association of resilience with health-related quality of life and depression in multiple myeloma and its precursors: results of a German cross-sectional study.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06987708 (Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance), which is not on this map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Myeloma (SM): A Prospective Intervention Pilot Study
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Smoldering multiple myeloma: a multi-country mixed-methods study on disease perceptions and patient treatment preferences.Future oncology (London, England) · 2026Article
- Distress and symptom burden in patients with monoclonal gammopathy of undetermined significance and smoldering myeloma.Blood advances · 2025Article
- [Resilience as an integral component of action competence in internal medicine].Innere Medizin (Heidelberg, Germany) · 2025Review
- The impact of divergent forms of social support on health-related quality of life in patients with multiple myeloma and its precursor states.Journal of cancer research and clinical oncology · 2024Article
- Psychological toxicity in classical hematology.European journal of haematology · 2023Review
- A Focus on Relapsed Multiple Myeloma.Journal of the advanced practitioner in oncology · 2022Article
- Impact of Patient Resilience on Outcomes of Open Brostrom-Gould Lateral Ligament Repair.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2021Article
- Higher fasting C-peptide is associated with post-stroke depression: a multicenter prospective cohort study.BMC neurology · 2021Article
- Patients with precursor disease exhibit similar psychological distress and mental HRQOL as patients with active myeloma.Blood cancer journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the relation between resilience, health-related quality of life (HRQOL) and depression in multiple myeloma (MM) and its premalignant stages. MM is one of the most frequent haematological disorders. It is regularly preceded by asymptomatic stages of the disease namely monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM). Survivors have to cope with mental and physical impairment in terms of HRQOL and depression. The concept of resilience refers to a person's ability to adapt to adversity.
designCross-sectional study.
settingMM outpatient department at a University Hospital in Germany (tertiary care).
participants292 consecutive patients from our MM outpatient department. OUTCOME MEASURES: HRQOL, depression and psychological resilience were assessed with validated questionnaires.
resultsRegression analyses were performed to determine associations between resilience, HRQOL and depression. 98 patients (33.6%) had a new diagnosis of active MM, 106 patients (36.3%) were already treated for MM and 88 patients had the diagnosis of a precursor (MGUS or SMM; 30.1%) of MM. Multivariate linear regression analyses revealed a strong positive impact of resilience on physical (b 7.20; 95% CI 4.43 to 9.98; p<0.001) and mental (b 12.12; 95% CI 9.36 to 14.87; p<0.001) HRQOL. Ordered logistic regression analysis showed that the odds for higher depression severity were lowered for individuals with a high level of resilience in comparison to the individuals with a low level of resilience (OR 0.11; 95% CI 0.06 to 0.19; p<0.001).
conclusionsResilience may be a protective factor in the disease trajectory of MM and its precursors. As a next step, future research should focus on longitudinal assessments at various time points to elucidate the role of resilience in one of the most frequent haematological malignancies.
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