Evidence map›Paper›PMID 30061417›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Rachel D Mullen, Ying Wang, Bin Liu, Emma L Moore, Richard R Behringer

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. SP7: from Bone Development to Skeletal Disease.Current osteoporosis reports · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Frontiers in endocrinology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rachel D MullenDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0001-6737-2640
Ying WangDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Bin LiuDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Emma L MooreDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0003-4116-918X
Richard R BehringerDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030; rrb@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
TRAINING PROGRAM IN MOLECULAR GENETICS OF CANCERT32CA009299 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOZANO, GUILLERMINA · 1985 to 2014
$4.7M
Molecular Genetics of Female Reproductive TractR01HD030284 · NICHD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BEHRINGER, RICHARD R · 1994 to 2013
$4.5M
Female Reproductive Tract Development in the MouseR37HD030284 · NICHD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BEHRINGER, RICHARD R · 2014 to 2023
$4.2M
Upgrading an existing NIKON A1-confocal with LUNV Laser Launch and DU-G detectorS10OD024976 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOZANO, GUILLERMINA · 2018 to 2018
$202k
NCI NIH HHS P30 CA016672NCI NIH HHS T32 CA009299NICHD NIH HHS R01 HD030284NICHD NIH HHS R37 HD030284NIH HHS S10 OD024976
6 · The paper itself

Abstract

In mammals, the developing reproductive tract primordium of male and female fetuses consists of the Wolffian duct and the Müllerian duct (MD), two epithelial tube pairs surrounded by mesenchyme. During male development, mesenchyme-epithelia interactions mediate MD regression to prevent its development into a uterus, oviduct, and upper vagina. It is well established that transforming growth factor-β family member anti-Müllerian hormone (AMH) secreted from the fetal testis and its type 1 and 2 receptors expressed in MD mesenchyme regulate MD regression. However, little is known about the molecular network regulating downstream actions of AMH signaling. To identify potential AMH-induced genes and regulatory networks controlling MD regression in a global nonbiased manner, we examined transcriptome differences in MD mesenchyme between males (AMH signaling on) and females (AMH signaling off) by RNA-seq analysis of purified fetal MD mesenchymal cells. This analysis found 82 genes up-regulated in males during MD regression and identified

Indexed as

AnimalsAnti-Mullerian Hormonebeta CateninGene Expression ProfilingMaleMiceMice, Inbred C57BLMullerian DuctsSignal TransductionSp7 Transcription FactorAnti-Mullerian Hormonebeta CateninCTNNB1 protein, mouseSp7 protein, mouseSp7 Transcription Factoranti-Müllerian hormoneMüllerian duct regressionOsterixreproductive tract developmentsex differentiation

Identifiers

PMID30061417
PMCPMC6099909
OpenAlexW2783079008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.