ArticleProceedings of the National Academy of Sciences of the United States of America2018
Rheotaxis-based separation of sperm with progressive motility using a microfluidic corral system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- Microfluidics for in vitro fertilization: from science to clinical validation.Human reproduction update · 2026Review
- Female reproductive tract-on-a-chip for selecting sperm with ultra-low DNA fragmentation index.Microsystems & nanoengineering · 2026Article
- Let the female tract choose: finding the sperm to enhanceAnimal reproduction · 2026Article
- Identification of the governing equation of stimulus-response data for run-and-tumble dynamics.PLoS computational biology · 2025Article
- Simple and rapid microfluidic device for processing raw human semen and separation of motile sperm based on their intrinsic behavior and morphology.Scientific reports · 2025Article
- Microfluidic Sorting Can Be Applied for Assisted Reproduction Sperm Selection in Different Cases of Semen Abnormalities.Life (Basel, Switzerland) · 2025Article
- Tunable motile sperm separation based on sperm persistence in migrating through shear barriers.Biomicrofluidics · 2024Article
- Advances in microfluidic technology for sperm screening and in vitro fertilization.Analytical and bioanalytical chemistry · 2024Review
- Qualified sperm selection based on the rheotaxis and thigmotaxis in a microfluidic system.Biomedical engineering letters · 2023Article
- Design of a gradient-rheotaxis microfluidic chip for sorting of high-quality Sperm with progressive motility.iScience · 2023Article
- Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies†.Biology of reproduction · 2023Article
- A novel microfluidic device with parallel channels for sperm separation using spermatozoa intrinsic behaviors.Scientific reports · 2023Article
- Lab-on-chip (LoC) application for quality sperm selection: An undelivered promise?Open research Europe · 2023Review
- β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.Cell reports. Medicine · 2022Article
- Separation of motile human sperms in a T-shaped sealed microchannel.Biomedical engineering letters · 2022Article
- New insights into sperm rheotaxis, agglutination and bundle formation in Sharkasi chickens based on an in vitro study.Scientific reports · 2022Article
- Multi-dimensional-double-spiral (MDDS) inertial microfluidic platform for sperm isolation directly from the raw semen sample.Scientific reports · 2022Article
- The influence of the female reproductive tract and sperm features on the design of microfluidic sperm-sorting devices.Journal of assisted reproduction and genetics · 2022Review
- Simulating nature in sperm selection for assisted reproduction.Nature reviews. Urology · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The separation of motile sperm from semen samples is sought after for medical infertility treatments. In this work, we demonstrate a high-throughput microfluidic device that can passively isolate motile sperm within corrals inside a fluid channel, separating them from the rest of the diluted sample. Using finite element method simulations and proposing a model for sperm motion, we investigated how flow rate can provide a rheotaxis zone in front of the corral for sperm to move upstream/downstream depending on their motility. Using three different flow rates that provided shear rates above the minimum value within the rheotaxis zone, we experimentally tested the device with human and bovine semen. By taking advantage of the rheotactic behavior of sperm, this microfluidic device is able to corral motile sperm with progressive velocities in the range of 48-93 μm⋅s
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