Evidence map›Paper›PMID 30061291›Full record

ArticleAntimicrobial agents and chemotherapy2018

Genetic Determinants of Penicillin Tolerance in Vibrio cholerae.

Anna I Weaver, Shannon G Murphy, Benjamin D Umans, Srikar Tallavajhala, Ikenna Onyekwere, Stephen Wittels, Jung-Ho Shin, Michael VanNieuwenhze, Matthew K Waldor, Tobias Dörr

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. A role for the Gram-negative outer membrane in bacterial shape determination.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Insights into Carbapenem Resistance inInternational journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Understanding tolerance to cell wall-active antibiotics.Annals of the New York Academy of Sciences · 2021
    Review
  16. σMolecular microbiology · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Antibiotic tolerance.PLoS pathogens · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Anna I Weaver *Department of Microbiology, Cornell University, Ithaca, New York, USA.
Shannon G Murphy *Department of Microbiology, Cornell University, Ithaca, New York, USA.
Benjamin D UmansHoward Hughes Medical Institute and Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Srikar TallavajhalaWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
Ikenna OnyekwereDepartment of Microbiology, Cornell University, Ithaca, New York, USA.
Stephen WittelsHoward Hughes Medical Institute and Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Jung-Ho ShinDepartment of Microbiology, Cornell University, Ithaca, New York, USA.
Michael VanNieuwenhzeDepartment of Molecular and Cellular Biochemistry and Department of Biology, Indiana University, Bloomington, Indiana, USA.
Matthew K WaldorHoward Hughes Medical Institute and Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Tobias DörrDepartment of Microbiology, Cornell University, Ithaca, New York, USA tdoerr@cornell.edu.
Cornell University · USHoward Hughes Medical Institute · USBrigham and Women's Hospital · USIndiana University Bloomington · US

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Dynamics of bacterial peptidoglycan synthesisR01GM113172 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI BRUN, YVES V, VANNIEUWENHZE, MICHAEL S · 2015 to 2018
$3.5M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI042347NIGMS NIH HHS R01 GM113172
6 · The paper itself

Abstract

Many bacteria are resistant to killing (tolerant) by typically bactericidal antibiotics due to their ability to counteract drug-induced cell damage.

Indexed as

Cell WallDrug ToleranceGene Expression Regulation, BacterialLipid APenicillin-Binding ProteinsPenicillinsPeptidoglycanVibrio choleraeLipid APenicillin-Binding ProteinsPenicillinsPeptidoglycanantibiotic tolerancebeta-lactamcell wall synthesisouter membranepenicillin-binding proteinspeptidoglycan

Identifiers

PMID30061291
PMCPMC6153846
OpenAlexW2950128307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.