Evidence map›Paper›PMID 30061287›Full record

ArticleAntimicrobial agents and chemotherapy2018

Novel Approaches To Kill Toxoplasma gondii by Exploiting the Uncontrolled Uptake of Unsaturated Fatty Acids and Vulnerability to Lipid Storage Inhibition of the Parasite.

Sabrina J Nolan, Julia D Romano, John T Kline, Isabelle Coppens

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 61 citations in OpenAlex.

  1. The live attenuatedResearch square · 2026
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  2. Quercetin ReducesInternational journal of molecular sciences · 2026
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  10. Frontiers in immunology · 2025
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  13. Reference Gene Selection for RT-qPCR Normalization inInternational journal of molecular sciences · 2024
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  15. Host cell-specific metabolism of linoleic acid controlsbioRxiv : the preprint server for biology · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Potent In Vitro and In Vivo Effects ofTropical medicine and infectious disease · 2023
    Article
  20. Evaluation of the Anti-Antibiotics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sabrina J NolanDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Julia D RomanoDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
John T KlineUnited States Department of Defense, Fort Meade, Maryland, USA.
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA icoppens@jhsph.edu.
Johns Hopkins University · USUnited States Department of Defense · US

Funding

Targeting of host vesicles to the vacuole of Toxoplasma and lipid cargo sortingR01AI060767 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2004 to 2020
$5.1M
Neutral lipid metabolism during Toxoplasma infectionR01AI138714 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI060767NIAID NIH HHS R01 AI138714
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsFatty Acids, MonounsaturatedFatty Acids, UnsaturatedLinoleic AcidLipid DropletsOleic AcidPalmitic AcidToxoplasmaFatty Acids, MonounsaturatedFatty Acids, UnsaturatedLinoleic AcidOleic AcidPalmitic Acidpalmitoleic acidDGAT inhibitionfatty acid uptake and storagelipid dropletT863 parasiticidal activityToxoplasma gondii

Identifiers

PMID30061287
PMCPMC6153790
OpenAlexW2883915328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.