Evidence map›Paper›PMID 30061194›Full record

Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2018

Clinical relevance of bacterial resistance in lower respiratory tract infection in primary care: secondary analysis of a multicentre European trial.

Jolien Teepe, Berna Dl Broekhuizen, Herman Goossens, Patricia Marinka Hordijk, Katherine Loens, Christine Lammens, Margareta Ieven, Paul Little, Chris C Butler, Samuel Coenen and 4 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Jolien TeepeDepartment of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Berna Dl BroekhuizenDepartment of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Herman GoossensLaboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Patricia Marinka HordijkDepartment of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Katherine LoensLaboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Christine LammensLaboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Margareta IevenLaboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Paul LittleDepartment of Primary Care and Population Sciences, University of Southampton Medical School, Southampton, UK.
Chris C ButlerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Samuel CoenenLaboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, and Centre for General Practice, Department of Primary and Interdisciplinary Care (ELIZA) Antwerp, University of Antwerp, Antwerp, Belgium.
Maciek Godycki-CwirkoDepartment of Family and Community Medicine, Faculty of Health Sciences, Medical University of Lodz, Lodz, Poland.
Birgitta Henriques-NormarkDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Clinical Microbiology, Karolinska University Hospital, and the Swedish Institute for Infectious Disease Control, Stockholm, Sweden.
Theo Jm VerheijDepartment of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
GRACE consortium
University Medical Center Utrecht · NLUniversity of Antwerp · BEUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of antimicrobial resistance on clinical outcomes in patients with lower respiratory tract infection in primary care is largely unknown.

aimTo determine the illness course of infections with resistant bacteria in adults presenting to primary care with acute cough. DESIGN AND

settingSecondary analysis of a multicentre European trial in primary care.

methodA total of 2061 adults with acute cough (lasting ≤28 days) were recruited from primary care and randomised to amoxicillin or placebo. To reflect the natural course of disease, only patients in the placebo group (

resultsOf the 834 patients with diary records, 104 showed

conclusionThe illness course of antibiotic-resistant lower respiratory tract infection does not differ from that caused by antibiotic-sensitive bacteria.

Indexed as

Primary Health CareAcute DiseaseAdultAgedAmoxicillinAnti-Bacterial AgentsCoughDrug Resistance, BacterialFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedPlacebosRespiratory Tract InfectionsTreatment OutcomeAmoxicillinAnti-Bacterial AgentsPlacebosantimicrobial drug resistancecoughlower respiratory tract infectionprimary careprognosis

Identifiers

PMID30061194
PMCPMC6104862
OpenAlexW2886289254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.