Evidence map›Paper›PMID 30061177›Full record

ArticleBioscience reports2018

Differential expression of NPM, GSTA3, and GNMT in mouse liver following long-term

Lan Yi, Hongxiang Mu, Nan Hu, Jing Sun, Jie Yin, Keren Dai, Dingxin Long, Dexin Ding

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lan YiKey Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang 421001, Hunan Province, P.R. China.
Hongxiang MuInstitute of Cytology and Genetics, College of Pharmaceutical and Biological Science, University of South China, Hengyang 421001, Hunan Province, P.R. China.
Nan HuKey Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang 421001, Hunan Province, P.R. China.
Jing SunInstitute of Cytology and Genetics, College of Pharmaceutical and Biological Science, University of South China, Hengyang 421001, Hunan Province, P.R. China.
Jie YinKey Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang 421001, Hunan Province, P.R. China.
Keren DaiInstitute of Cytology and Genetics, College of Pharmaceutical and Biological Science, University of South China, Hengyang 421001, Hunan Province, P.R. China.
Dingxin LongKey Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang 421001, Hunan Province, P.R. China.
Dexin DingKey Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang 421001, Hunan Province, P.R. China dingdxzzz@163.com.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uranium tailings (UT) are formed as a byproduct of uranium mining and are of potential risk to living organisms. In the present study, we sought to identify potential biomarkers associated with chronic exposure to low dose rate γ radiation originating from UT. We exposed C57BL/6J mice to 30, 100, or 250 μGy/h of gamma radiation originating from UT samples. Nine animals were included in each treatment group. We observed that the liver central vein was significantly enlarged in mice exposed to dose rates of 100 and 250 μGy/h, when compared with nonirradiated controls. Using proteomic techniques, we identified 18 proteins that were differentially expressed (by a factor of at least 2.5-fold) in exposed animals, when compared with controls. We chose glycine N-methyltransferase (GNMT), glutathione S-transferase A3 (GSTA3), and nucleophosmin (NPM) for further investigations. Our data showed that GNMT (at 100 and 250 μGy/h) and NPM (at 250 μGy/h) were up-regulated, and GSTA3 was down-regulated in all of the irradiated groups, indicating that their expression is modulated by chronic gamma radiation exposure. GNMT, GSTA3, and NPM may therefore prove useful as biomarkers of gamma radiation exposure associated with UT. The mechanisms underlying those changes need to be further studied.

Indexed as

UraniumAnimalsBiomarkersComputational BiologyDose-Response Relationship, RadiationElectrophoresis, Gel, Two-DimensionalGamma RaysGlutathione TransferaseGlycine N-MethyltransferaseLiverMaleMice, Inbred C57BLNuclear ProteinsNucleophosminProteomicsRadiation ExposureBiomarkersGlutathione TransferaseGlycine N-MethyltransferaseGnmt protein, mouseGSTA3 protein, mouseNuclear ProteinsNucleophosminUraniumC57BL/6J micechronic gamma radiationliverprotein expressionuranium tailings

Identifiers

PMID30061177
PMCPMC6200700
OpenAlexW2886387488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.