Evidence map›Paper›PMID 30061176›Full record

ArticleBioscience reports2018

Cerebral blood flow alteration following acute myocardial infarction in mice.

Abdullah Kaplan, Andriy Yabluchanskiy, Rana Ghali, Raffaele Altara, George W Booz, Fouad A Zouein

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  8. An apoptosis inhibitor suppresses microglial and astrocytic activation after cardiac ischemia/reperfusion injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Abdullah KaplanDepartment of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon.
Andriy YabluchanskiyTranslational Geroscience Laboratory, Reynold's Oklahoma Center on Aging, Department of Geriatric Medicine, Oklahoma City, OK, U.S.A.
Rana GhaliDepartment of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon.
Raffaele AltaraInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
George W BoozDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, U.S.A.
Fouad A ZoueinDepartment of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon fouadzouein@outlook.com.
American University of Beirut · LBUniversity of Oslo · NO

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PAUL G SPICER · 2013 to 2026
$68.2M
NIGMS NIH HHS U54 GM104938
6 · The paper itself

Abstract

Heart failure is associated with low cardiac output (CO) and low brain perfusion that imposes a significant risk for accelerated brain ageing and Alzheimer's disease (AD) development. Although clinical heart failure can emerge several years following acute myocardial infarction (AMI), the impact of AMI on cerebral blood flow (CBF) at early stages and up to 30 days following MI is unknown. Sixteen months old male mice underwent left anterior descending (LAD) coronary artery ligation. Hemodynamics analyses were performed at baseline and at days 1, 7, and 30 post-MI. Left ventricular (LV) ejection fraction (EF), LV volumes, CO, and right common carotid artery (RCCA) diameter were recorded by echocardiography. RCCA flow (RCCA FL) was measured by Doppler echocardiography. LV volumes consistently increased (

Indexed as

AnimalsBrainCerebrovascular CirculationEchocardiography, DopplerElectrocardiographyMaleMice, Inbred C57BLMyocardial InfarctionVentricular RemodelingAgingCardiac Outputcerebral blood flowmyocardial infarctionright common coronary artery flow

Identifiers

PMID30061176
PMCPMC6123068
OpenAlexW2886889632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.