ArticleThorax2018
Environmental exposures and systemic hypertension are risk factors for decline in lung function.
Article in Thorax, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of hypertension and its relationship with altitude in highland areas: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Pooled it
- Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population.Frontiers in public health · 2023Trial
- Chronic Hypobaric Hypoxia at High Altitudes Aggravates Chronic Obstructive Pulmonary Disease in Mice.Journal of inflammation research · 2026Article
- Understanding the causal effects and heterogeneity between metabolic syndrome and lung function: a nationwide prospective cohort study in China.Diabetology & metabolic syndrome · 2025Article
- Prevalence of chronic obstructive pulmonary disease in high-risk populations at low, intermediate, high altitudes: a population based cross-sectional study in Yunnan Province, China.BMC pulmonary medicine · 2025Article
- Lung function and nonalcoholic fatty liver disease: a Mendelian randomization study.Archives of medical science : AMS · 2025Article
- Clinical relevance of lung function trajectory clusters in middle-aged and older adults.ERJ open research · 2024Article
- Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes.Frontiers in medicine · 2024Review
- The Impact of Different Smoking Behavior on Pulmonary Function and Pulmonary Hypertension Among Chinese Male Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2024Article
- Global Burden of Chronic Obstructive Pulmonary Disease Through 2050.JAMA network open · 2023Article
- Hypertensive disorders of pregnancy and risk of asthma and chronic obstructive pulmonary disease: a prospective cohort study.Lancet regional health. Americas · 2023Article
- Comparison of the lower limit of normal to the fixed ratio method for the diagnosis of airflow obstruction at high altitudes: a large cross-sectional survey of subjects living between 3000-4700 m above sea level.European journal of medical research · 2023Article
- Investigation and Analysis of Risk Factors and Psychological Status of Chronic Obstructive Pulmonary Disease in Permanent Residents Aged 40 or Older in Hongyuan County, Aba Prefecture, Sichuan Province.International journal of chronic obstructive pulmonary disease · 2023Article
- Article
- Peru - Progress in health and sciences in 200 years of independence.Lancet regional health. Americas · 2022Review
- Black Carbon Content in Airway Macrophages is Associated with Reduced CD80 Expression and Increased Exacerbations in Former Smokers With COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Prevalence of chronic obstructive pulmonary disease at high altitude: a systematic review and meta-analysis.PeerJ · 2020Article
- High COPD prevalence at high altitude: does household air pollution play a role?The European respiratory journal · 2019Article
- Decreased lung function is associated with risk of developing non-alcoholic fatty liver disease: A longitudinal cohort study.PloS one · 2019Article
- Global, regional and national trends in burden of chronic obstructive pulmonary disease from 2000 to 2021 and the prediction for 2030.Chronic respiratory diseaseArticle
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Authors and funding
9 authors.
Funding
Abstract
backgroundChronic lung disease is a leading contributor to the global disease burden; however, beyond tobacco smoke, we do not fully understand what risk factors contribute to lung function decline in low-income and middle-income countries.
methodsWe collected sociodemographic and clinical data in a randomly selected, age-stratified, sex-stratified and site-stratified population-based sample of 3048 adults aged ≥35 years from four resource-poor settings in Peru. We assessed baseline and annual pre-bronchodilator and post-bronchodilator lung function over 3 years. We used linear mixed-effects models to assess biological, socioeconomic and environmental risk factors associated with accelerated lung function decline.
resultsMean±SD enrolment age was 55.4±12.5 years, 49.2% were male and mean follow-up time was 2.36 (SD 0.61) years. Mean annual pre-bronchodilator FEV
conclusionUrbanisation, living at high altitude and hypertension were associated with accelerated lung function decline in a population with low daily smoking prevalence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.