Trial reportBlood2018
Silent infarcts in sickle cell disease occur in the border zone region and are associated with low cerebral blood flow.
Trial report in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.American journal of hematology · 2025Trial
- Quantifying dilated perivascular spaces in children with sickle cell disease.Pediatric blood & cancer · 2024Trial
- The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease.Blood · 2024Trial
- Cerebral oxygen metabolism in adults with sickle cell disease.American journal of hematology · 2020Trial
- Trial
- Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease.Haematologica · 2019Trial
- White matter has impaired resting oxygen delivery in sickle cell patients.American journal of hematology · 2019Trial
- Cerebral Blood Transit in Sickle Cell Anemia.Journal of magnetic resonance imaging : JMRI · 2026Article
- Blame It on My (Arterial) Youth: How Childhood Vascular Morphology Shapes the Risk of Cerebral Vasculopathy in Sickle Cell Disease.American journal of hematology · 2026Article
- Reliability of diffuse optical spectroscopies for evaluation of cerebral hemometabolic stress in children with sickle cell anemia.Biomedical optics express · 2026Article
- Regional brain age is decreased in children with sickle cell anemia.Blood advances · 2026Article
- Assessment of cerebral autoregulation and cerebral perfusion in patients with sickle cell disease using frequency-domain near-infrared spectroscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers.Neuroimage. Reports · 2025Article
- Sensitivity and Specificity of a Signaling Question for Surveillance of Cognitive Functioning in Pediatric Sickle Cell Disease.Pediatric blood & cancer · 2025Article
- Unraveling the Complex Genomic Interplay of Sickle Cell Disease Among the Saudi Population: A Case-Control GWAS Analysis.International journal of molecular sciences · 2025Article
- Comparison of Asymptomatic Brain Lesions Between Thalassemia Major and Sickle Cell Anemia Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Cerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.Neurology · 2025Article
- Brain Age Modeling and Cognitive Outcomes in Young Adults With and Without Sickle Cell Anemia.JAMA network open · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Silent cerebral infarcts (SCIs) are associated with cognitive impairment in sickle cell anemia (SCA). SCI risk factors include low hemoglobin and elevated systolic blood pressure; however, mechanisms underlying their development are unclear. Using the largest prospective study evaluating SCIs in pediatric SCA, we identified brain regions with increased SCI density. We tested the hypothesis that infarct density is greatest within regions in which cerebral blood flow is lowest, further restricting cerebral oxygen delivery in the setting of chronic anemia. Neuroradiology and neurology committees reached a consensus of SCIs in 286 children in the Silent Infarct Transfusion (SIT) Trial. Each infarct was outlined and coregistered to a brain atlas to create an infarct density map. To evaluate cerebral blood flow as a function of infarct density, pseudocontinuous arterial spin labeling was performed in an independent pediatric SCA cohort. Blood flow maps were aligned to the SIT Trial infarct density map. Mean blood flow within low, moderate, and high infarct density regions from the SIT Trial were compared. Logistic regression evaluated clinical and imaging predictors of overt stroke at 3-year follow-up. The SIT Trial infarct density map revealed increased SCI density in the deep white matter of the frontal and parietal lobes. A relatively small region, measuring 5.6% of brain volume, encompassed SCIs from 90% of children. Cerebral blood flow was lowest in the region of highest infarct density (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.