Evidence map›Paper›PMID 30061105›Full record

ArticleThe Journal of cell biology2018

Myoepithelial cells are a dynamic barrier to epithelial dissemination.

Orit Katarina Sirka, Eliah R Shamir, Andrew J Ewald

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 84 citations in OpenAlex.

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  8. Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Orit Katarina SirkaDepartments of Cell Biology, Oncology, and Biomedical Engineering, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD.
Eliah R ShamirDepartments of Cell Biology, Oncology, and Biomedical Engineering, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD.
Andrew J EwaldDepartments of Cell Biology, Oncology, and Biomedical Engineering, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD andrew.ewald@jhmi.edu.ORCID 0000-0002-1964-0740
Johns Hopkins University · US

Funding

The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI SUN, SEAN X · 2016 to 2020
$9.9M
Pathway Discovery and Target Validation for Outgrowth of Breast Cancer MetastasesU01CA217846 · NCI · JOHNS HOPKINS UNIVERSITY · PI BADER, JOEL S., EWALD, ANDREW JOSEF · 2017 to 2021
$4.8M
NCI NIH HHS U01 CA217846NCI NIH HHS U54 CA210173
6 · The paper itself

Abstract

The mammary epithelium is composed of an inner luminal and surrounding myoepithelial cell layer. The presence of cancer cells beyond the myoepithelium defines invasive breast cancer, yet the role of the myoepithelium during invasion remains unclear. We developed a 3D organotypic culture assay to model this process through lineage-specific expression of the prometastatic transcription factor

Indexed as

AnimalsCadherinsFemaleMammary Glands, AnimalMammary Neoplasms, AnimalMiceMice, TransgenicMyoepitheliomaNeoplasm InvasivenessNeoplasm ProteinsNuclear ProteinsTwist-Related Protein 1CadherinsNeoplasm ProteinsNuclear ProteinsTwist1 protein, mouseTwist-Related Protein 1

Identifiers

PMID30061105
PMCPMC6168248
OpenAlexW2887832628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.