Evidence map›Paper›PMID 30060725›Full record

ReviewThe Journal of international medical research2018

Intracytoplasmic sperm injection outcome of ejaculated spermatozoa from a man with mosaic Klinefelter's Syndrome: case report and literature review.

Yang Yu, Qi Xi, Jili Jing, Linlin Li, Hongguo Zhang, Ruizhi Liu, Yuan Pan

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yang YuCentre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China.
Qi XiCentre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China.
Jili JingCentre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China.
Linlin LiCentre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China.
Hongguo ZhangCentre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China.
Ruizhi LiuCentre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China.
Yuan PanCentre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective To report a case of abortion after intracytoplasmic sperm injection (ICSI) with ejaculated spermatozoa obtained from a man with mosaic Klinefelter's syndrome. Methods Sperm nuclei from the patient were analyzed by fluorescence in situ hybridization, and the disomy frequencies for chromosome 18 and the sex chromosomes were determined. A literature review of the ICSI outcome of ejaculated sperm in patients with Klinefelter's syndrome was also performed. Results A total of 108 spermatozoa nuclei were analyzed. Of these, 102 sperm cells were normal with an X18 (55.56%) or Y18 (38.89%) chromosome pattern. Three cells with XX18 (2.78%) and three cells with YY18 (2.78%) signals were detected. The fetus stopped developing in the eighth week. The karyotype determined by an analysis of the abortive tissue was 46, XY. The literature review identified a total of 12 patients who were analyzed in 11 reports. The fertilization rate was 80.9%, and the live birth rate per transfer was 71.4%. Conclusions ICSI with ejaculated spermatozoa from men with Klinefelter's syndrome can lead to pregnancy, for which the risk of transmission of chromosomal aneuploidy is low.

Indexed as

Sperm Injections, IntracytoplasmicAbortion, SpontaneousAdultChromosome AberrationsEjaculationFemaleFetal DeathHumansInfertility, MaleIn Situ Hybridization, FluorescenceKaryotypingKlinefelter SyndromeMaleMosaicismOligospermiaPregnancyfluorescent in situ hybridizationinfertilityintracytoplasmic sperm injection outcomekaryotypeKlinefelter’s syndromespermatozoa

Identifiers

PMID30060725
PMCPMC6166348
OpenAlexW2887744386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.